Positive tendency toward synchronous use of acetaminophen and ibuprofen in treating patients with patent ductus arteriosus
| Autor: | Nima Mehdizadegan, Khadijehsadat Najib, Hamid Amoozgar, Fatemeh Sabzevari, Roya Oboodi, Shahnaz Pourarian, Mozhgan Moghtaderi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
lcsh:Internal medicine lcsh:Diseases of the circulatory (Cardiovascular) system Combination therapy lcsh:Medicine Gestational Age Dinoprostone law.invention Randomized controlled trial law Ductus arteriosus medicine Humans Initial treatment lcsh:RC31-1245 Ductus Arteriosus Patent acetaminophen ibuprofen business.industry organic chemicals Anti-Inflammatory Agents Non-Steroidal lcsh:R Infant Newborn Infant Analgesics Non-Narcotic Ibuprofen Acetaminophen Treatment Outcome medicine.anatomical_structure Echocardiography neonate patent ductus arteriosus lcsh:RC666-701 Anesthesia Concomitant Drug Therapy Combination Female Safety Cardiology and Cardiovascular Medicine business Biomarkers Infant Premature Combination drug medicine.drug |
| Zdroj: | Türk Kardiyoloji Derneği Arşivi, Vol 48, Iss 6, Pp 605-612 (2020) |
| ISSN: | 1016-5169 |
| Popis: | Objective Spontaneous closure of the ductus arteriosus often fails to occur in premature newborns and this condition can be associated with increased morbidity and mortality. The initial treatment to achieve closure of the opening is pharmacological, and various nonsteroidal anti-inflammatory drugs may be used. The aim of this study was to determine whether combining acetaminophen with ibuprofen is more effective than the individual use of these drugs to treat patent ductus arteriosus (PDA). Methods The present randomized, controlled trial study included 154 premature newborns with PDA. The patients were randomized into 3 groups: the acetaminophen group (n=67), ibuprofen group (n=68), and combination drug group (n=19). Echocardiography was performed before initiating the medication and after completing a first and second course of treatment. Blood markers were measured to assess the safety of the 3 types of therapy. Results After the first course of treatment, PDA closure was seen in 76.1% of the infants in the acetaminophen group, 76.4% of those in the ibuprofen group, and 78.9% of the combination therapy group (p=0.97). The closure rate after a second course of treatment was 43.7% in the acetaminophen group, 62.5% in the ibuprofen group, and 100% in the combination group. There were no complications attributed to the 3 methods of treatment used. Conclusion Concomitant use of acetaminophen and ibuprofen can be an effective option for closure of PDA. Other studies with a larger sample size are recommended in order to confirm these results. |
| Databáze: | OpenAIRE |
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