Cerebral Arterial Spasm – A Controlled Trial of Nimodipine in Patients with Subarachnoid Hemorrhage
| Autor: | G S, Allen, H S, Ahn, T J, Preziosi, R, Battye, S C, Boone, S N, Chou, D L, Kelly, B K, Weir, R A, Crabbe, P J, Lavik, S B, Rosenbloom, F C, Dorsey, C R, Ingram, D E, Mellits, L A, Bertsch, D P, Boisvert, M B, Hundley, R K, Johnson, J A, Strom, C R, Transou |
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| Rok vydání: | 1983 |
| Předmět: |
Adult
Male Subarachnoid hemorrhage Adolescent Placebo law.invention Random Allocation Basal (phylogenetics) Double-Blind Method Randomized controlled trial Recurrence law medicine Humans Prospective Studies cardiovascular diseases Prospective cohort study Nimodipine Aged Clinical Trials as Topic business.industry Nicotinic Acids Intracranial Aneurysm General Medicine Middle Aged Subarachnoid Hemorrhage Calcium Channel Blockers medicine.disease nervous system diseases Clinical trial Exact test Ischemic Attack Transient Anesthesia Female Tomography X-Ray Computed business medicine.drug |
| Zdroj: | New England Journal of Medicine. 308:619-624 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm198303173081103 |
| Popis: | We enrolled 125 neurologically normal patients with intracranial aneurysms in a multi-institution, prospective, double-blind, randomized, placebo-controlled trial within 96 hours of their subarachnoid hemorrhage, to determine whether treatment with the calcium blocker nimodipine would prevent or reduce the severity of ischemic neurologic deficits from arterial spasm. A deficit from cerebral arterial spasm that persisted and was severe or caused death by the end of the 21-day treatment period occurred in 8 of 60 patients given placebo and in 1 of 56 given nimodipine (P = 0.03, Fisher's exact test). Analysis of the amount of basal subarachnoid blood on pre-entry CAT scans in patients with deficits from spasm showed that an increase in subarachnoid blood was not associated with a worse neurologic outcome among patients who received nimodipine, unlike the situation in patients given a placebo. There were no side effects from nimodipine. We conclude that nimodipine should be given to patients who are neurologically normal after subarachnoid hemorrhage in order to reduce the occurrence of severe neurologic deficits due to cerebral arterial spasm. |
| Databáze: | OpenAIRE |
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