Fever response induced by intravenous and intracerebroventricular injection of pyrogen in thyroidectomised and protein-calorie malnourished rabbits
| Autor: | C. A A Silva, I. R. Pela, Marcos Macari, R. S. Viana |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Lipopolysaccharides
Male medicine.medical_specialty Calorie Lipopolysaccharide Fever Physiology medicine.medical_treatment Clinical Biochemistry Protein-Energy Malnutrition chemistry.chemical_compound Physiology (medical) Internal medicine medicine Escherichia coli Animals Receptor Injections Intraventricular Lagomorpha biology business.industry Pyrogens Thyroid Thyroidectomy Interleukin Thermoregulation biology.organism_classification medicine.anatomical_structure Endocrinology chemistry Immunology Injections Intravenous Rabbits business |
| Zdroj: | Pflugers Archiv : European journal of physiology. 415(4) |
| ISSN: | 0031-6768 |
| Popis: | The development of a fever in response to intravenous (IV, 1.5 micrograms/kg body mass) and intracerebroventricular (ICV, 1.5 micrograms/animal) injections of Escherichia coli lipopolysaccharide (LPS) was studied in control, thyroidectomised and protein-calorie malnourished rabbits (New Zealand Whites, n = 55). ICV injection of LPS in control rabbits produced a fever response, the characteristics of which differed from those obtained after IV pyrogen injection. Thyroid deficiency caused an attenuated fever response, irrespective of whether LPS had been administered by IV or ICV injection. Protein-calorie malnourished rabbits showed a smaller fever response after IV or ICV pyrogen injections. Malnourished rabbits, refed over a period of 15 days, showed a typical biphasic fever response, but with lower magnitude than controls. The results of these experiments suggest that ICV injection of LPS is not an appropriate model for the study of fever mechanisms in disease states, and that the attenuated fever response observed in protein-calorie malnourished rabbits may be related, at least in part, to a decreased ability to produce the endogenous pyrogen interleukin-1. |
| Databáze: | OpenAIRE |
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