Different effects of 26-week dietary intake of rapeseed oil and soybean oil on plasma lipid levels, glucose-6-phosphate dehydrogenase activity and cyclooxygenase-2 expression in spontaneously hypertensive rats
| Autor: | Tomoko Nagata, Yukiko Naito, Makiko Kuwagata, Harumi Okuyama, Yoshiaki Saito, Kikuko Kasama, Naoki Ohara |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Glucose-6-phosphate dehydrogenase activity Erythrocytes food.ingredient Blood lipids Glucosephosphate Dehydrogenase Biology Kidney Toxicology medicine.disease_cause Soybean oil Fatty Acids Monounsaturated food Rats Inbred SHR Internal medicine medicine Animals Plant Oils Cyclooxygenase 2 Inhibitors Myocardium Brain General Medicine Juxtaglomerular apparatus Immunohistochemistry Lipids Enzyme assay Rats Soybean Oil medicine.anatomical_structure Endocrinology Liver Cyclooxygenase 2 Hypertension Lipogenesis biology.protein Rapeseed Oil Oxidative stress Food Science |
| Zdroj: | Food and Chemical Toxicology. 46:2573-2579 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2008.04.015 |
| Popis: | We intended to determine whether or not dietary canola oil (CO) elevates plasma lipids and oxidative stress, since both of these are, possibly, related to the CO-induced life shortening through exacerbation of hypertension-associated vascular lesions found in stroke-prone spontaneously hypertensive rats (SHRSP). Spontaneously hypertensive rats (SHR) were used in this study to avoid a potential bias in the results due to the irregular death by stroke seen in SHRSP. SHR were fed for 26 weeks on a chow containing either, 10 wt/wt% of CO or soybean oil (SO), i.e., the control. Elevated plasma lipids and glucose-6-phosphate dehydrogenase (G6PD) activation in the liver and erythrocyte were found in SHR fed CO compared to that fed SO, while anti-oxidative enzymes other than G6PD were not activated. The CO diet brought about significant vascular lesions in the kidney, in which abundant cyclooxygenase-2 (COX-2) positive foci were immunochemically located in the juxtaglomerular apparatus. These results suggest that dietary CO induces a hyperlipidemic condition, in which G6PD may serve as an NADPH provider, and aggravates genetic diseases in SHR (also, probably, in SHRSP). The increased COX-2 expression indicates a role of renin-angiotensin-aldosterone system activation in the increased vascular lesions, whereas the effects of oxidative stress remain unclear. |
| Databáze: | OpenAIRE |
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