Activation of the motivation-related ventral striatum during delusional experience
| Autor: | Tuukka T. Raij, Tapani Riekki, Tuula Kieseppä, Jaana Suvisaari, Teemu Mäntylä, Eva Rikandi |
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| Přispěvatelé: | Department of Neuroscience and Biomedical Engineering, University of Helsinki, National Institute for Health and Welfare, Aalto-yliopisto, Aalto University, Clinicum, Department of Psychiatry, Department of Psychology and Logopedics, Medicum, Institute for Molecular Medicine Finland, HUS Psychiatry |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Psychosis SYMPTOMS Adolescent Brain mapping 3124 Neurology and psychiatry Delusions Article lcsh:RC321-571 DOPAMINE 03 medical and health sciences Cellular and Molecular Neuroscience Young Adult PSYCHOSIS 0302 clinical medicine COGNITIVE STATES Delusion Dopamine SCHIZOPHRENIA medicine Humans NETWORK PHENOMENOLOGY Young adult lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Brain Mapping Motivation medicine.diagnostic_test ABERRANT SALIENCE Ventral striatum PERSECUTORY DELUSIONS medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Psychotic Disorders Meta-analysis Ventral Striatum Female medicine.symptom Psychology Functional magnetic resonance imaging HALLUCINATIONS 030217 neurology & neurosurgery Clinical psychology medicine.drug |
| Zdroj: | Translational Psychiatry Translational Psychiatry, Vol 8, Iss 1, Pp 1-8 (2018) |
| ISSN: | 2158-3188 |
| Popis: | Delusion is the most characteristic symptom of psychosis, occurring in almost all first-episode psychosis patients. The motivational salience hypothesis suggests delusion to originate from the experience of abnormal motivational salience. Whether the motivation-related brain circuitries are activated during the actual delusional experience remains, however, unknown. We used a forced-choice answering tree at random intervals during functional magnetic resonance imaging to capture delusional and non-delusional spontaneous experiences in patients with first-episode psychosis (n = 31) or clinical high-risk state (n = 7). The motivation-related brain regions were identified by an automated meta-analysis of 149 studies. Thirteen first-episode patients reported both delusional and non-delusional spontaneous experiences. In these patients, delusional experiences were related to stronger activation of the ventral striatum in both hemispheres. This activation overlapped with the most strongly motivation-related brain regions. These findings provide an empirical link between the actual delusional experience and the motivational salience hypothesis. Further use and development of the present methods in localizing the neurobiological basis of the most characteristic symptoms may be useful in the search for etiopathogenic pathways that result in psychotic disorders. |
| Databáze: | OpenAIRE |
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