PLGA/PLCA casting and PLGA/PDPA electrospinning bilayer film for prevention of postoperative adhesion
Autor: | Bing Wang, Lijing Niu, Chengyi Shen, Chengmin Feng, Xiao-Ming Zhang |
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Rok vydání: | 2018 |
Předmět: |
Male
Materials science Biomedical Engineering Tissue Adhesions 02 engineering and technology Biomaterials 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Polylactic Acid-Polyglycolic Acid Copolymer Pregnadienes Animals Bilayer Membranes Artificial Adhesion Postoperative adhesion 021001 nanoscience & nanotechnology Casting Electrospinning PLGA Physical Barrier chemistry 030220 oncology & carcinogenesis Female Rabbits 0210 nano-technology Layer (electronics) Biomedical engineering |
Zdroj: | Journal of biomedical materials research. Part B, Applied biomaterials. 107(6) |
ISSN: | 1552-4981 |
Popis: | Postoperative adhesion is a common complication and preventing adhesions during or immediately after operation is particularly important. The application of solid barrier materials represents the most successful clinical strategy to prevent postoperative adhesion. However, a simple physical barrier effect might be insufficient in preventing adhesion satisfactorily. Multilayered structures can be designed with an outer layer as the barrier and an inner layer to respond to relative drug release. In this article, bilayer film composed of a PLGA/PLCA casting layer as barrier and PLGA/PDPA electrospinning layer to respond to the release of anti-fibrosis drug l-Phe was designed and synthesized. The adhesion prevention effect of the above PLGA/PLCA/PDPA bilayer film was examined and compared with single PLGA/PLCA casting film and single PLGA/PDPA electrospinning film by applying rabbit sidewall defect-cecum abrasion model. As demonstrated by histological observation and immunohistochemical analysis, the bilayer film was the most effective of the three films in postoperative adhesion prevention in terms of both physical barrier effect and anti-fibrosis effect of the PDPA macromolecular prodrug. Besides anti-fibrosis effect, PDPA could also suppress excess proliferation of vascular endothelial cells and microvessel caused by long-term stimulation of implantation materials to the surrounding tissues. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2030-2039, 2019. |
Databáze: | OpenAIRE |
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