Is Zolpidem Associated with Increased Risk of Fractures in the Elderly with Sleep Disorders? A Nationwide Case Cross-Over Study in Taiwan
| Autor: | Yun Ju Yin, Chia Lun Yeh, Yih Jing Tang, Hua Chin Lee, Hui Ling Huang, William C. Chu, Hui-Wen Yeh, Wei Shan Chiang, Shinn-Ying Ho, Nian-Sheng Tzeng, Hung An Chen, Fang Ying Chu |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Sleep Wake Disorders medicine.medical_specialty Zolpidem Pyridines medicine.drug_class Osteoporosis Taiwan Poison control lcsh:Medicine Benzodiazepines Fractures Bone Risk Factors Internal medicine medicine Humans Hypnotics and Sedatives lcsh:Science Depression (differential diagnoses) Aged Aged 80 and over Geriatrics Benzodiazepine Cross-Over Studies Multidisciplinary business.industry musculoskeletal neural and ocular physiology lcsh:R Age Factors Case-control study medicine.disease humanities Case-Control Studies Physical therapy Female lcsh:Q business Diazepam Research Article medicine.drug |
| Zdroj: | PLoS ONE, Vol 10, Iss 12, p e0146030 (2015) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND: We conducted a study using a case-crossover design to clarify the risk of acute effects of zolpidem and benzodiazepine on all-sites of fractures in the elderly. DESIGN OF STUDY: Case-crossover design. METHODS AND MATERIALS: Elderly enrollees (n = 6010) in Taiwan's National Health Insurance Research Database with zolpidem or benzodiazepine use were analyzed for the risk of developing fractures. RESULTS: After adjusting for medications such as antipsychotics, antidepressants, and diuretics, or comorbidities such as hypertension, osteoarthritis, osteoporosis, rheumatoid arthritis and depression, neither zolpidem nor benzodiazepine was found to be associated with increased risk in all-sites fractures. Subjects without depression were found to have an increased risk of fractures. Diazepam is the only benzodiazepine with increased risk of fractures after adjusting for medications and comorbidities. Hip and spine were particular sites for increased fracture risk, but following adjustment for comorbidities, the associations were found to be insignificant. CONCLUSION: Neither zolpidem nor benzodiazepine was associated with increased risk of all-site fractures in this case cross-over study after adjusting for medications or comorbidities in elderly individuals with insomnia. Clinicians should balance the benefits and risks for prescribing zolpidem or benzodiazepine in the elderly accordingly. Language: en |
| Databáze: | OpenAIRE |
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