Hyaluronan delivery by polymer demixing in polysaccharide-based hydrogels and membranes for biomedical applications
| Autor: | Andrea Travan, Massimiliano Borgogna, Francesca Scognamiglio, Sergio Paoletti, Lorena Tarusha, Mario Grassi, Eleonora Marsich, Ivan Donati |
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| Přispěvatelé: | Travan, Andrea, Scognamiglio, Francesca, Borgogna, MASSIMILIANO ANTONIO, Marsich, Eleonora, Donati, Ivan, Tarusha, Lorena, Grassi, Mario, Paoletti, Sergio |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Materials Chemistry2506 Metals and Alloys Polymers and Plastics 02 engineering and technology 010402 general chemistry Polysaccharide 01 natural sciences chemistry.chemical_compound Polysaccharides Materials Testing Polymer chemistry Hyaluronic acid Materials Chemistry Humans Hyaluronic Acid Mechanical Phenomena Skin Materials Chemistry2506 Metals and Alloy chemistry.chemical_classification Drug Carriers Wound Healing Wound healing activity Membranes Organic Chemistry Membrane Membranes Artificial Hydrogels Polymer 021001 nanoscience & nanotechnology In vitro 0104 chemical sciences Hydrogel Drug Liberation chemistry Self-healing hydrogels Biophysics Polymer demixing Rheology 0210 nano-technology Drug carrier Wound healing |
| Zdroj: | Carbohydrate Polymers. 150:408-418 |
| ISSN: | 0144-8617 |
| Popis: | Alginate-based membranes containing hyaluronic acid (HA) were manufactured by freeze-drying calcium-reticulated hydrogels. The study of the distribution of the two macromolecules within the hydrogel enabled to highlight a polymer demixing mechanism that tends to segregate HA in the external parts of the constructs. Resistance and pliability of the membranes were tuned, while release and degradation studies enabled to quantify the diffusion of both polysaccharides in physiological solution and to measure the viable lifetime of the membranes. Biological studies in vitro proved that the liquid extracts from the HA-containing membranes stimulate wound healing and that fibroblasts are able to colonize the membranes. Overall, such novel alginate-HA membranes represent a promising solution for several medical needs, in particular for wound treatment, giving the possibility to provide an in situ administration of HA from a resorbable device. |
| Databáze: | OpenAIRE |
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