Emerging important roles of circRNAs in human cancer and other diseases
| Autor: | Cai Zhi Zhang, Hongtao Ren, Yong Huang, Xiong Jianli |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Medicine (General) Diseases Review Article Computational biology QH426-470 Biology Biochemistry 03 medical and health sciences Exon R5-920 0302 clinical medicine microRNA Genetics Function Molecular Biology Gene Biogenesis Genetics (clinical) Cancer Intron RNA Cell Biology 030104 developmental biology 030220 oncology & carcinogenesis RNA splicing CircRNAs Function (biology) Regulation |
| Zdroj: | Genes & Diseases Genes and Diseases, Vol 8, Iss 4, Pp 412-423 (2021) |
| ISSN: | 2352-3042 |
| DOI: | 10.1016/j.gendis.2020.07.012 |
| Popis: | CircRNAs are a large class of endogenous single-stranded RNA that is different from other linear RNA, which are produced by back-splicing and fusion of either exons, introns, or both exon-intron into covalently closed loops. CircRNAs are found in almost all living organisms and have emerged as potentially important players effecting on all life activities. It was characterized by stable structure, resistant to RNA degradation, highly abundance and conservation and tissue-specific expression. Early circRNAs were ignored as a by-product of meaningless abnormally cut RNA and had little biological function. Currently, circRNAs have become a research hotspot due to its special characteristics. CircRNAs could function as miRNA sponges, interfere with splicing and bind to protein to regulate the expression of parental genes and so on. In recent years, an increasing number of studies have revealed that circRNAs are closely related to a series of physiological and pathological processes. Additionally, circRNAs play an important role in the occurrence and development of a variety of diseases, suggesting circRNAs may be as novel indicators or biomarkers for cancer and other diseases with which they are associated. In this article, we review the biogenesis, biological functions of circRNAs and recent advances in circRNAs research in human diseases. Results will provide new insights on the roles and new ideas of circRNAs for the diagnosis and treatment of diseases and possible directions and approach for future circRNA applications. |
| Databáze: | OpenAIRE |
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