Sustained Release of Hydrophilic l-ascorbic acid 2-phosphate Magnesium from Electrospun Polycaprolactone Scaffold—A Study across Blend, Coaxial, and Emulsion Electrospinning Techniques
| Autor: | Yuan Siang Lui, Pei Wen Jessica Toh, Xinxin Zhao, Say Chye Joachim Loo |
|---|---|
| Přispěvatelé: | School of Materials Science & Engineering, Singapore Centre for Environmental Life Sciences Engineering |
| Rok vydání: | 2014 |
| Předmět: |
Scaffold
Materials science chemistry.chemical_element release lcsh:Technology chemistry.chemical_compound ascorbate-2-phosphate General Materials Science Composite material lcsh:Microscopy electrospinning lcsh:QC120-168.85 Solvent system lcsh:QH201-278.5 lcsh:T Magnesium Communication technology industry and agriculture Electrospinning chemistry Chemical engineering lcsh:TA1-2040 Polycaprolactone Emulsion Engineering::Materials::Ecomaterials [DRNTU] lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering L-ascorbic acid 2-phosphate Coaxial lcsh:Engineering (General). Civil engineering (General) lcsh:TK1-9971 |
| Zdroj: | Materials, Vol 7, Iss 11, Pp 7398-7408 (2014) Materials |
| ISSN: | 1996-1944 |
| Popis: | The purpose of this study was to achieve a sustained release of hydrophilic l-ascorbic acid 2-phosphate magnesium (ASP) from electrospun polycaprolactone (PCL) scaffolds, so as to promote the osteogenic differentiation of stem cells for bone tissue engineering (TE). ASP was loaded and electrospun together with PCL via three electrospinning techniques, i.e., coaxial, emulsion, and blend electrospinning. For blend electrospinning, binary solvent systems of dichloromethane–methanol (DCM–MeOH) and dichloromethane–dimethylformamide (DCM–DMF) were used to achieve the desired ASP release through the effect of solvent polarity and volatility. The scaffold prepared via a blend electrospinning technique with a binary solvent system of DCM–MeOH at a 7:3 ratio demonstrated a desirable, sustained ASP release profile for as long as two weeks, with minimal burst release. However, an undesirable burst release (~100%) was observed within the first 24 h for scaffolds prepared by coaxial electrospinning. Scaffolds prepared by emulsion electrospinning displayed poorer mechanical properties. Sustained releasing blend electrospun scaffold could be a good potential candidate as an ASP-eluting scaffold for bone tissue engineering. Published version |
| Databáze: | OpenAIRE |
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