Conformationally locked nucleosides. Synthesis and hybridization properties of oligodeoxynucleotides containing 2′,4′-C-bridged 2′-deoxynucleosides
| Autor: | Guangyi Wang, Jean-Luc Girardet, Vesna Stoisavljevic, Esmir Gunic |
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| Rok vydání: | 1999 |
| Předmět: |
Models
Molecular Antisense DNA Bicyclic molecule Stereochemistry Organic Chemistry Clinical Biochemistry Oligonucleotides Pharmaceutical Science RNA Nucleosides Crystallography X-Ray Desoxyribonucleotide Biochemistry Chemical synthesis Molecular hybridization Deoxyribonucleotide chemistry.chemical_compound chemistry Drug Discovery Molecular Medicine Molecular Biology DNA |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 9:1147-1150 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(99)00146-8 |
| Popis: | A conformationally locked, 2',4'-C-bridged 2'-deoxyribofuranoside2 was condensed with silylated pyrimidines to give 2',4'-C-bridged bicyclonucleosides, which were converted to the phosphoramidites and incorporated into oligodeoxynucleotides (ODNs). The hybridization data of the modified ODNs to DNA and RNA are presented. |
| Databáze: | OpenAIRE |
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