Myeloid hyperplasia in the SENCAR mouse: differentiation from granulocytic leukemia
| Autor: | M. Robinson, Gary L. Knutsen, Richard E. Long |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1986 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Health Toxicology and Mutagenesis Spleen Mice Inbred Strains Biology medicine.disease_cause Pathogenesis Diagnosis Differential Mice hemic and lymphatic diseases Terminology as Topic medicine Animals Erythropoiesis Hyperplasia Public Health Environmental and Occupational Health Organ Size medicine.disease Leukemia medicine.anatomical_structure SENCAR Mouse Leukemia Myeloid Differential diagnosis Carcinogenesis Megakaryocytes Research Article Granulocytes |
| Zdroj: | Environmental Health Perspectives |
| ISSN: | 0091-6765 |
| Popis: | The term myeloid hyperplasia has been used interchangeably with many other terms to describe an increased production of granulocytes, megakaryocytes, and erythrocytes in the spleen and other organs in the mouse. This process is occasionally misdiagnosed as granulocytic leukemia. This paper reviews some of the terms used interchangeably with myeloid hyperplasia and describes criteria that can be used to differentiate myeloid hyperplasia from granulocytic leukemia. Additionally, the results of a study in which myeloid hyperplasia was induced following the formation of skin tumors in SENCAR mice is discussed. In this study, positive correlations were found between skin lesions, the spleen weight, and histologic appearance of the spleen. The liver rarely showed microscopic changes of myeloid hyperplasia unless the spleen weighed at least 1.0% of the body weight. Images FIGURE 3. FIGURE 4. FIGURE 5. FIGURE 6. FIGURE 7. FIGURE 8. FIGURE 9. |
| Databáze: | OpenAIRE |
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