Parkinson's disease diffusion MRI is not affected by acute antiparkinsonian medication

Autor: David E. Vaillancourt, Edward Ofori, Jae Woo Chung, Priyank Shukla, Christopher W. Hess, Roxana G. Burciu, Michael S. Okun
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Longitudinal study
Parkinson's disease
Antiparkinsonian medication
Cognitive Neuroscience
Substantia nigra
lcsh:Computer applications to medicine. Medical informatics
Severity of Illness Index
lcsh:RC346-429
Antiparkinson Agents
03 medical and health sciences
0302 clinical medicine
Internal medicine
Fractional anisotropy
medicine
Image Processing
Computer-Assisted
Humans
Radiology
Nuclear Medicine and imaging
lcsh:Neurology. Diseases of the nervous system
Aged
medicine.diagnostic_test
business.industry
Putamen
Free-water
Brain
Magnetic resonance imaging
Regular Article
dMRI
Parkinson Disease
Middle Aged
medicine.disease
3. Good health
Free-water corrected fractional anisotropy
Subthalamic nucleus
030104 developmental biology
Diffusion Magnetic Resonance Imaging
Neurology
Cardiology
Physical therapy
lcsh:R858-859.7
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Diffusion MRI
Zdroj: NeuroImage : Clinical
NeuroImage: Clinical, Vol 14, Iss C, Pp 417-421 (2017)
ISSN: 2213-1582
Popis: Objective A prior longitudinal study demonstrates that free-water diffusion magnetic resonance imaging (dMRI) tracks progression in the substantia nigra (Ofori et al., 2015b). Here, we test the acute effects of antiparkinsonian medication on this established imaging progression marker for the first time. Methods Fifteen PD patients underwent dMRI OFF and ON-medication one day apart. ON-medication, patients were tested approximately 45 min after their usual dose of antiparkinsonian medication. OFF-medication, patients were tested after not taking antiparkinsonian medication for > 12 h. OFF and ON-medication was counter-balanced across subjects. For dMRI, we computed free-water and free-water corrected fractional anisotropy (FAt) within the following regions: caudate, putamen, substantia nigra, and subthalamic nucleus. Results ON-medication significantly reduced parkinsonian motor symptoms compared with OFF-medication (p
Highlights • Effects of dopaminergic medication on PD progression markers • Investigate dMRI biomarkers in early PD • Acute PD medication does not alter the progression markers.
Databáze: OpenAIRE
Externí odkaz: