The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis
| Autor: | Jian Q. Yao, Massoud Daheshia |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
business.industry
Cartilage Interleukin-1beta Synovial Membrane Immunology Anti-Inflammatory Agents Chronic pain Disease Osteoarthritis medicine.disease Up-Regulation Proinflammatory cytokine Pathogenesis Disease Models Animal medicine.anatomical_structure Rheumatology Downregulation and upregulation Animals Humans Immunology and Allergy Medicine Signal transduction business |
| Zdroj: | The Journal of Rheumatology. 35:2306-2312 |
| ISSN: | 1499-2752 0315-162X |
| DOI: | 10.3899/jrheum.080346 |
| Popis: | Osteoarthritis (OA) is a major disabling disease and is ranked as a major cause of chronic pain in adults. The pathology of the illness is characterized by a loss of articular cartilage leading to narrowing of joint space, increased joint friction, potential structural remodeling, persistent pain, and functional impairment. The proinflammatory cytokine interleukin 1beta (IL-1beta) has several chemical and bioactive characteristics allowing this catabolic protein to be involved in initiation and progression of OA. We review the current understanding of the pathogenesis of OA, and how upregulation of IL-1beta initiates a cascade of intracellular events that can culminate in activation of proteinases, creation of a pro-destructive articular milieu, suppression of anabolic pathways, and a decrease in the synthesis of cartilage extracellular matrix. Therapeutic approaches to block the action of IL-1beta and overcome its signal transduction to curtail disease progression are discussed. |
| Databáze: | OpenAIRE |
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