Allosteric modulation of the nicotinic acetylcholine receptor by physostigmine

Autor:	Vyskocil F, Jan Krusek, Tomáš Hendrych, Lucie Svobodová
Rok vydání:	2005
Předmět:	Physostigmine Patch-Clamp Techniques Time Factors Receptors Nicotinic General Biochemistry Genetics and Molecular Biology Ganglion type nicotinic receptor History and Philosophy of Science Allosteric Regulation Muscarinic acetylcholine receptor M5 Muscarinic acetylcholine receptor Chlorocebus aethiops medicine Animals Neurons Dose-Response Relationship Drug Chemistry General Neuroscience Nicotinic acetylcholine receptor Nicotinic agonist COS Cells Biophysics Cholinesterase Inhibitors Alpha-4 beta-2 nicotinic receptor Acetylcholine medicine.drug
Zdroj:	Annals of the New York Academy of Sciences. 1048
ISSN:	0077-8923
Popis:	The action of physostigmine on mouse muscle nicotinic acetylcholine receptor expressed in the COS-7 cell line was studied by the patch-clamp technique. Physostigmine accelerated, by allosteric modulation, the rate of desensitization of whole cell currents induced by acetylcholine and decreased the maximal amplitude in concentration-dependent manner.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0813fed6c072d9715e175ace2070c35 https://pubmed.ncbi.nlm.nih.gov/16154951 Zobrazit plný text záznamu Plný text