Significance of biglycan and osteopontin as non-invasive markers of liver fibrosis in patients with chronic hepatitis B virus and chronic hepatitis C virus
| Autor: | Ali Sobhy, M Mohammed Fakhry, Hamed O. Khalifa, Haitham A. Azeem, Ahmed M Ashmawy |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Liver Cirrhosis
Male 030213 general clinical medicine medicine.medical_specialty Hepatitis C virus 030204 cardiovascular system & hematology medicine.disease_cause Gastroenterology General Biochemistry Genetics and Molecular Biology Virus 03 medical and health sciences Hepatitis B Chronic 0302 clinical medicine Fibrosis Internal medicine Biglycan medicine Humans Osteopontin biology medicine.diagnostic_test business.industry Area under the curve General Medicine Hepatitis C Chronic Middle Aged medicine.disease Liver biopsy biology.protein Female Hepatic fibrosis business Biomarkers |
| Zdroj: | Journal of Investigative Medicine. 67:681-685 |
| ISSN: | 1708-8267 1081-5589 |
| DOI: | 10.1136/jim-2018-000840 |
| Popis: | Several studies were performed to evaluate the degree of liver fibrosis by non-invasive markers. We aimed to assess the diagnostic value of both biglycan (BGN) and osteopontin (OPN) as non-invasive markers of hepatic fibrosis in patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC). This study was performed on 100 patients with CHB virus, 100 patients with CHC virus and 100 normal controls. All participants were subjected to the following laboratory tests: hemoglobin, platelet, alanine aminotransferase, aspartate aminotransferase, albumin, international normalized ratio, HBs Ag, hepatitis C virus (HCV) antibody, hepatitis B virus DNA, HCV RNA, liver biopsy, BGN and OPN. We found that BGN level was significantly increased in the CHB group compared with the controls (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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