Dual Effects of Indoleamine 2,3-Dioxygenase Inhibitors on the Therapeutic Effects of Cyclophosphamide and Cycloplatam on Ehrlich Ascites Tumor in Mice
| Autor: | L. A. Bogdanova, Valery P. Nikolin, T. S. Morozkova, Dmitrii G. Mazhukin, V. I. Kaledin, S. A. Amitina, Nelly A. Popova |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Cycloplatam Organoplatinum Compounds Cyclophosphamide Antineoplastic Agents Pharmacology Biology Ehrlich ascites General Biochemistry Genetics and Molecular Biology Mice Oximes medicine Animals Indoleamine-Pyrrole 2 3 -Dioxygenase Drug Interactions Ethyl pyruvate Enzyme Inhibitors Carcinoma Ehrlich Tumor Pyruvates Indoleamine 2 3-dioxygenase Mice Inbred ICR Antitumor immunity Therapeutic effect General Medicine Immunity Innate Tumor Burden Immunology Drug Therapy Combination Female medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 157:506-509 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-014-2602-1 |
| Popis: | Ethyl pyruvate, an inhibitor of indoleamine 2,3-dioxygenase, slightly suppressed the growth of transplantable Ehrlich tumor in mice and signifi cantly potentiated the therapeutic effect of cyclophosphamide. Another inhibitor amidoxime produced a similar effect. However, both ethyl pyruvate and amidoxime signifi cantly reduced the effect of cycloplatam therapy. The observed changes can be stipulated by different effects of cyclophosphamide and cycloplatam on the subpopulations of lymphoid cells taking part in the formation of antitumor immunity and resistance to tumors. |
| Databáze: | OpenAIRE |
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