Ocular Clinical Signs and Diagnostic Tests Most Compatible With Keratoconjunctivitis Sicca: A Latent Class Approach
| Autor: | Lindsey A. Criswell, Thomas M. Lietman, Vatinee Y Bunya, Esen K. Akpek, John A. Gonzales, Stephen Shiboski, Caroline H. Shiboski, Jennifer Rose-Nussbaumer, Gerami D. Seitzman |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Saliva tear breakup time fluorescein Clinical Sciences Keratoconjunctivitis Sicca Predictor variables Salivary gland biopsy Ophthalmology & Optometry Article Young Adult Schirmer 1 Opthalmology and Optometry Ophthalmology medicine KERATOCONJUNCTIVITIS SICCA Humans tear osmolarity Registries Sjogren syndrome Dental/Oral and Craniofacial Disease screening and diagnosis business.industry Diagnostic test Gold standard (test) Tear osmolarity eye diseases Staining Detection Cross-Sectional Studies Lissamine Green Tears Female business Digestive Diseases ocular staining score Conjunctiva 4.2 Evaluation of markers and technologies |
| Zdroj: | Cornea, vol 39, iss 8 Cornea |
| Popis: | Author(s): Gonzales, John A; Shiboski, Stephen C; Bunya, Vatinee Y; Akpek, Esen K; Rose-Nussbaumer, Jennifer; Seitzman, Gerami D; Criswell, Lindsey A; Shiboski, Caroline H; Lietman, Thomas M | Abstract: PurposeTo evaluate the ocular signs and tests for keratoconjunctivitis sicca (KCS) in the absence of a gold standard.MethodsCross-sectional study of participants from the Sjogren's International Collaborative Clinical Alliance (SICCA) registry. Participants had oral/ocular/rheumatologic examinations, blood/saliva samples collected, and salivary gland biopsy. Latent class analysis (LCA) identified clusters of patients based on 3 to 4 predictor variables relating to signs or tests of KCS. The resulting model-based "gold standard" classification formed the basis for estimated sensitivity and specificity associated with these predictors.ResultsA total of 3514 participants were enrolled into SICCA, with 52.9% classified as SS. LCA revealed a best-fit model with 2 groups. For the gold standard-positive group, an abnormal tear breakup time, ocular staining score (OSS), and Schirmer I had a sensitivity of 99.5%, 91.0%, and 47.4%, respectively. For the gold standard-negative group, an abnormal tear breakup time, OSS, and Schirmer I had a specificity of 32.0%, 84.0%, and 88.5%, respectively. OSS components (fluorescein and lissamine staining), exhibited a sensitivity of 82.6% and 90.5%, respectively, in the gold standard-positive group, whereas these signs in the gold standard-negative group had a specificity of 88.8% and 73.0%, respectively.ConclusionsOSS and its components (fluorescein and lissamine staining) differentiated 2 groups from each other better than other KCS parameters and had relatively high sensitivity and specificity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|