HIV Distal Neuropathic Pain Is Associated with Smaller Ventral Posterior Cingulate Cortex
| Autor: | Cherine Akkari, Dongzhe Wang, J. Hampton Atkinson, Austin Rennels, George Kesidis, Colm G. Connolly, Jisu Lee, David J. Miller, Gregory G. Brown, Alexandra Schlein, Christine Fennema-Notestine, Chelsea Sanders, Sung Kim, Donald Franklin, Mark Jenkinson, Sarah L. Archibald, John R Keltner, Stephanie Corkran, Florin Vaida, Ronald J. Ellis, Igor Grant, Han Li |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Cingulate cortex brain volume HIV Infections HIV Distal Neuropathic Pain cingulate cortex 0302 clinical medicine pain Gray Matter Young adult anti-retroviral agents medicine.diagnostic_test General Medicine Middle Aged Magnetic Resonance Imaging peripheral nerves Anesthesia Neuropathic pain Brain size Female Posterior Cingulate Cortex neuropathy due to human immunodeficiency virus Adult brain Gyrus Cinguli Young Adult 03 medical and health sciences Structural Magnetic Resonance Imaging Image Interpretation Computer-Assisted medicine Humans Aged neuropathic pain business.industry HIV HIV seropositivity Magnetic resonance imaging Voxel-based morphometry HIV infection medicine.disease PSYCHOLOGY PSYCHIATRY IMAGING & BRAIN NEUROSCIENCE SECTION 030104 developmental biology Anesthesiology and Pain Medicine Posterior cingulate Neuralgia neuropathy Neurology (clinical) voxel business Voxel-Based Morphometry 030217 neurology & neurosurgery |
| Zdroj: | Keltner, JR; Connolly, CG; Vaida, F; Jenkinson, M; Fennema-Notestine, C; Archibald, S; et al.(2017). HIV Distal Neuropathic Pain Is Associated with Smaller Ventral Posterior Cingulate Cortex. PAIN MEDICINE, 18(3), 428-440. doi: 10.1093/pm/pnw180. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/86z0191k |
| ISSN: | 1526-4637 1526-2375 |
| Popis: | Objective. Despite modern antiretroviral therapy, HIV-associated neuropathy is one of the most prevalent, disabling and treatment-resistant complications of HIV disease. The presence and intensity of distal neuropathic pain is not fully explained by the degree of peripheral nerve damage. A better understanding of brain structure in HIV distal neuropathic pain may help explain why some patients with HIV neuropathy report pain while the majority does not. Previously, we reported that more intense distal neuropathic pain was associated with smaller total cerebral cortical gray matter volumes. The objective of this study was to determine which parts of the cortex are smaller. Methods. HIV positive individuals with and without distal neuropathic pain enrolled in the multisite (N = 233) CNS HIV Antiretroviral Treatment Effects (CHARTER) study underwent structural brain magnetic resonance imaging. Voxel-based morphometry was used to investigate regional brain volumes in these structural brain images. Results. Left ventral posterior cingulate cortex was smaller for HIV positive individuals with versus without distal neuropathic pain (peak P = 0.017; peak t = 5.15; MNI coordinates x = −6, y = −54, z = 20). Regional brain volumes within cortical gray matter structures typically associated with pain processing were also smaller for HIV positive individuals having higher intensity ratings of distal neuropathic pain. Conclusions. The posterior cingulate is thought to be involved in inhibiting the perception of painful stimuli. Mechanistically a smaller posterior cingulate cortex structure may be related to reduced anti-nociception contributing to increased distal neuropathic pain. |
| Databáze: | OpenAIRE |
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