Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites
| Autor: | He-Chuan Yang, Xiaopeng Qi, Jane Budd, Anders J. Hansen, Min-Sheng Peng, Philippe Gaubert, Meng Wang, Lubin Jiang, Olaogun S Charles, José Alfredo Samaniego, M. Thomas P. Gilbert, Yang Li, Yang Hu, Adeniyi C. Adeola, Mikkel-Holger S. Sinding, Oscar J Sanke, Guo-Dong Wang, Lu Wang, Tao Xu, Yan-Hu Liu, Xiaomin Guo, Ting-Ting Yin, Shyam Gopalakrishnan, Weiwei Zhai, Eli Knispel Rueness, Ya-Ping Zhang, Carlos Fernandes, Ya-ping Ma, Philip M Dawuda, Newton O. Otecko |
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| Přispěvatelé: | Kunming Institute of Zoology (KIZ), Chinese Academy of Sciences [Beijing] (CAS), Yunnan Agricultural University, Genome Institute of Singapore (GIS), Institut Pasteur de Shanghai, Académie des Sciences de Chine - Chinese Academy of Sciences (IPS-CAS), Réseau International des Instituts Pasteur (RIIP), University of Ibadan, Natural History Museum of Denmark, Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Natural History Museum [Oslo], University of Oslo (UiO), Centre for Ecology - Evolution and Environmental Changes (cE3c), Universidade de Lisboa = University of Lisbon (ULISBOA), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), University of Agriculture, Makurdi (UAM), Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences [Oslo], Faculty of Mathematics and Natural Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO)-Faculty of Mathematics and Natural Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), Institute of Zoology, Chinese Academy of Sciences [Beijing], Kunming Institute of Zoology, Chinese Academy of Science (CAS), University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Universidade de Lisboa (ULISBOA), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226 |
| Rok vydání: | 2017 |
| Předmět: |
Gene Flow
0301 basic medicine Demographic history Plasmodium Population African dogs Adaptive evolution antiparasite Adaptation Biological Introgression Zoology Biology Genome 03 medical and health sciences Dogs 0302 clinical medicine Antiparasite parasitic diseases Genetics medicine Animals Selection Genetic education Molecular Biology Ecology Evolution Behavior and Systematics Tropical Climate education.field_of_study adaptive evolution Wolves Natural selection [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health Whole Genome Sequencing [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] Genetic Variation demographic history medicine.disease Biological Evolution 3. Good health [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics 030104 developmental biology Africa Adaptation 030217 neurology & neurosurgery Malaria Founder effect |
| Zdroj: | Molecular Biology and Evolution Molecular Biology and Evolution, 2018, 35 (2), pp.287-298. ⟨10.1093/molbev/msx258⟩ Molecular Biology and Evolution, Oxford University Press (OUP), 2018, 35 (2), pp.287-298. ⟨10.1093/molbev/msx258⟩ Molecular biology and evolution |
| ISSN: | 0737-4038 1537-1719 |
| DOI: | 10.1093/molbev/msx258 |
| Popis: | Natural selection in domestic dogs is of great interest in evolutionary biology since dogs have migrated to every inhabited continent of the world alongside humans, and adapted to diverse environments. Here, we explored their demographic history and genetic basis of adaptation to the tropical African environment using whole genome analyses of 19 African indigenous dogs from Nigeria. Demographic analysis suggests that the ancestors of these dogs migrated into Africa from Eurasia 14,000 years ago and underwent a severe founder effect before population expansion. Admixture analysis further reveals that African dog genomes contain about 1.88–3.50% introgression from African golden wolves (Canis anthus). Population genetic analysis identifies 50 positively selected genes linked with immunity, angiogenesis, ultraviolet protection, as well as insulin secretion and sensitivity that may contribute to adaptation to tropical conditions. One of the positively selected genes, adhesion G protein-coupled receptor E1 (ADGRE1), has also been found to be association with severe malaria resistance in African human populations. Functional assessments showed that ADGRE1 provides protective host defense against Plasmodium infections. This result, together with the fact that the inflammatory response to canine babesiosis is similar to complicated falciparum malaria in humans, support the dogs as a model for the study of malaria control and treatment. This is a pre-copyedited, author-produced version of an article accepted for publication in [Molecular biology and evolution] following peer review. Locked until 10.10.2018 due to copyright restrictions. The version of record is available online at: https://academic.oup.com/mbe/article/35/2/287/4316110 |
| Databáze: | OpenAIRE |
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