Cell dynamics in the intestine of the mouse from late fetal life to maturity
| Autor: | Thomas M. O'Connor |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Male
medicine.medical_specialty Aging Mitotic index Population Cell Biology digestive system Andrology Mice Fetus Internal medicine medicine Animals education Postnatal day education.field_of_study digestive oral and skin physiology Organ Size Intestines medicine.anatomical_structure Endocrinology Animals Newborn Gestation Female Sex Anatomy Cell Division |
| Zdroj: | The American journal of anatomy. 118(2) |
| ISSN: | 0002-9106 |
| Popis: | A normal developmental pattern of the mitotic index, growth of villi and crypts, rate of cell extrusion, and number of villi per duodenal cross section is presented for mice ranging in age from the seventeenth day of gestation through 48 days after birth. These patterns are correlated with the normal increases in both length and weight of the intestine as a whole during this period. Two periods were observed during which there is a 25% reduction in the mitotic index. There is essentially no change in the mitotic index after the twenty-first postnatal day. Approximately 43% of the 48-day villus-crypt height is reached by birth, and approximately 83% of the 48-day level is reached by the twenty-first day. No extrusion zones were observed in mice before birth, and a threefold increase in the rate of extrusion was observed between the fifteenth and twenty-first postnatal day. Growth of the villus-crypt epithelial cell population appears to be a result of a rate of cell extrusion which is much lower in the young than in the adult animal. |
| Databáze: | OpenAIRE |
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