Targeted delivery of antibody conjugated liposomal drug carriers to rat myocardial infarction
| Autor: | Ramakrishna Nallamothu, George C. Wood, Andrew C. Issekutz, Christopher B. Pattillo, Georgina Perez-Liz, Luis Del Valle, Mohammad F. Kiani, Bin Wang, Robert C. Scott |
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| Rok vydání: | 2007 |
| Předmět: |
Male
P-selectin Anti-Inflammatory Agents Myocardial Infarction Bioengineering Pharmacology Applied Microbiology and Biotechnology Rats Sprague-Dawley Immunoliposome medicine Animals cardiovascular diseases Myocardial infarction Inflammation Drug Carriers Chemistry Cell adhesion molecule Myocardium Antibodies Monoclonal medicine.disease Rats Disease Models Animal P-Selectin Targeted drug delivery Liposomes Drug delivery Immunology cardiovascular system Drug carrier Ligation Biotechnology |
| Zdroj: | Biotechnology and Bioengineering. 96:795-802 |
| ISSN: | 1097-0290 0006-3592 |
| DOI: | 10.1002/bit.21233 |
| Popis: | Immunoliposome (IL) targeting to areas of inflammation after an acute myocardial infarction (MI) could provide the means by which pro-angiogenic compounds can be selectively targeted to the infarcted region. The adhesion of model drug carriers and ILs coated with an antibody to P-selectin was quantified in a rat model of MI following left coronary artery ligation. Anti-P-selectin coated model drug carriers showed a 140% and 180% increase in adhesion in the border zone of the MI 1 and 4 h post-MI, respectively. Radiolabeled anti-P-selectin ILs injected immediately post-MI and allowed to circulate 24 h showed an 83% increase in targeting to infarcted myocardium when compared to adjacent non-infarcted myocardium. Radiolabeled anti-P-selectin ILs injected 4 h post-MI and allowed to circulate for 24 h showed a 92% increase in accumulation in infarcted myocardium when compared to adjacent non-infarcted myocardium. Targeting to upregulated adhesion molecules on the endothelium provides a promising strategy for selectively delivering compounds to the infarct region of the myocardium using our liposomal-based drug delivery vehicle. |
| Databáze: | OpenAIRE |
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