Acinetobacter infections in a tertiary level intensive care unit in northern India: Epidemiology, clinical profiles and outcomes
| Autor: | Parmdeep Kaur, Sheeba Madhavan, Ashu Sara Mathai, Aroma Oberoi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent medicine.drug_class Antibiotics India lcsh:Infectious and parasitic diseases law.invention Young Adult law Internal medicine Intensive care Epidemiology medicine Humans lcsh:RC109-216 Aged Retrospective Studies Aged 80 and over Cross Infection biology business.industry lcsh:Public aspects of medicine Mortality rate Public Health Environmental and Occupational Health lcsh:RA1-1270 Retrospective cohort study General Medicine Middle Aged Acinetobacter biology.organism_classification medicine.disease Survival Analysis Intensive care unit Anti-Bacterial Agents Intensive Care Units Pneumonia Treatment Outcome Infectious Diseases Female business Acinetobacter Infections |
| Zdroj: | Journal of Infection and Public Health, Vol 5, Iss 2, Pp 145-152 (2012) |
| ISSN: | 1876-0341 |
| Popis: | Summary: Background: Nosocomial Acinetobacter infections are an increasing concern in intensive care units (ICU). Objectives: To study the demographic and clinical characteristics and the outcomes of ICU patients with Acinetobacter infections. Methods: A retrospective, 1-year audit of all Acinetobacter infections diagnosed in ICU patients between January 1 and December 31, 2009. Results: Acinetobacter infection occurred in 94 patients (108 episodes). The most common site of infection was the respiratory tract (83 patients, 76.85%), with medical patients being more susceptible than surgical patients to Acinetobacter lung infections (P = 0.04), particularly late-onset ventilator-associated pneumonia (VAP) (P = 0.04). The majority (63.8%) of infections were acquired in the ICU, and patients with ICU acquired infections were intubated significantly longer than the other patients (P = 0.02). Seventy percent of the infections were caused by multidrug-resistant (MDR) strains, and the overall crude mortality rate was over 70%. The most important factors affecting mortality were the duration of intubation (P = 0.001) and the inappropriate use of antibiotics (P = 0.021) after diagnosis of the infection. Conclusions: Acinetobacter infections are highly prevalent in the ICU, with medical patients being more susceptible to lung infections, particularly late-onset VAP. The early and appropriate selection of antibiotics is the most important determinant of survival among these patients. Keywords: Acinetobacter, Infection, Intensive care unit |
| Databáze: | OpenAIRE |
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