Tracheo-bronchial Mucociliary Clearance in Patients with Primary and Secondary Sjögren's Syndrome
| Autor: | P. Carta, G. Passiu, L Satta, P. Nurchis, G. Sanna, A. Mathieu, Alberto Cauli, Matteo Piga, G. L. Loi, R Pala, P. Garau |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Systemic disease Mucociliary clearance Eye disease Vital Capacity Immunology Bronchi Scintigraphy Gastroenterology Salivary Glands Rheumatology Reference Values Forced Expiratory Volume Immunopathology Internal medicine medicine Humans Immunology and Allergy Radionuclide Imaging Saliva Lung Aged medicine.diagnostic_test business.industry Respiratory disease food and beverages General Medicine Middle Aged medicine.disease Trachea SSS Sjogren's Syndrome Mucociliary Clearance Breathing Female business |
| Zdroj: | Scandinavian Journal of Rheumatology. 24:300-304 |
| ISSN: | 1502-7732 0300-9742 |
| DOI: | 10.3109/03009749509095167 |
| Popis: | We determined the tracheo-bronchial mucociliary clearance (MCC) in order to evaluate a possible impairment of this function in patients affected by Sjögren's syndrome (SS) with or without overt clinical symptoms of xerotrachea. The MCC was expressed as flow rate (mm/min) and studied in 22 non-smoking SS patients (10 pSS and 12 sSS) and in 8 control subjects by specifically adapted ventilation lung scintigraphy (VLS). The MCC in the control group was 5.9 +/- 1.1 mm/min. No values were produced for MCC in 16 SS patients (8 pSS and 8 sSS) in the time interval considered and were reduced in the remaining 6 SS patients (3.3 +/- 1.2 mm/min). In all nine cases with clinical evidence of xerotrachea no values for MCC were obtained. A significant correlation was found between the MCC values and the rate of stimulated salivary excretion determined by dynamic scialoscintigraphy in the same patients (p0.001). These preliminary data show that the majority of SS patients studied presented with MCC impairment, always found when clinical symptoms of xerotrachea were present. |
| Databáze: | OpenAIRE |
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