Extraction of Galphimines from Galphimia glauca with Supercritical Carbon Dioxide
| Autor: | Ricardo García Morales, Francisco Javier Verónico Sánchez, Octavio Elizalde Solís, Alejandro Zamilpa, Ma Dolores Pérez García, Jesús E Jiménez Ferrer, Jaime Tortoriello |
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| Rok vydání: | 2020 |
| Předmět: |
Galphimia glauca
Pharmaceutical Science 01 natural sciences High-performance liquid chromatography Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound 0404 agricultural biotechnology lcsh:Organic chemistry Drug Discovery Galphimia árnica roja Physical and Theoretical Chemistry supercritical extraction Chromatography High Pressure Liquid galphimine B Supercritical carbon dioxide Chromatography Plant Extracts 010405 organic chemistry Chemistry Organic Chemistry Extraction (chemistry) Supercritical fluid extraction carbon dioxide Chromatography Supercritical Fluid 04 agricultural and veterinary sciences kinetic modeling 040401 food science Triterpenes Supercritical fluid 0104 chemical sciences Volumetric flow rate Chemistry (miscellaneous) Yield (chemistry) Carbon dioxide Molecular Medicine |
| Zdroj: | Molecules Volume 25 Issue 3 Molecules, Vol 25, Iss 3, p 477 (2020) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25030477 |
| Popis: | The anti-depressive and anxiolytic effect of galphimine B (isolated from Galphimia glauca) has been demonstrated by researchers. Therefore, it is necessary to explore extraction techniques that produce materials with adequate quality for pharmaceutical applications. In this work, supercritical extractions of galphimines from Galphimia glauca were performed in the presence of carbon dioxide. Pressure, temperature, particle diameter, and flow rate effects were examined to explore the conditions with the highest yield and the concentration profile of galphimines in the studied interval. The identification of the nor-seco triterpenoids and galphimine B and E was carried out by HPLC analyses. The mathematical modeling of the extraction curves was attained by the approaches proposed by Sovová and Papamichail et al. According to results, the highest yield 2.22% was obtained at 323.15 K, 326 &mu m, 3 L/min, and 33.75 MPa. Meanwhile, the content of galphimine B in the extract was, on average, 19.5 mg· g&minus 1. |
| Databáze: | OpenAIRE |
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