Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study

Autor: Herbert Roeyers, Colm O'Dushlaine, Edmund J.S. Sonuga-Barke, Richard P. Ebstein, Ana Miranda, Aribert Rothenberger, Philip Asherson, Jessica Lasky-Su, Tobias Banaschewski, Stephen V. Faraone, Wai Chen, Fernando Mulas, Aisling Mulligan, Joseph A. Sergeant, Jan K. Buitelaar, Barbara Franke, Elaine Kenny, Benjamin M. Neale, Robert D. Oades, Kaixin Zhou, H. C. Steinhausen, Richard Anney, Michael Gill, Hanna Christiansen, Alejandro Arias-Vásquez
Přispěvatelé: University of Zurich
Rok vydání: 2008
Předmět:
Genetics and epigenetic pathways of disease [NCMLS 6]
2804 Cellular and Molecular Neuroscience
Medizin
Poison control
Comorbidity
Neuroinformatics [DCN 3]
Linkage Disequilibrium
Cohort Studies
2738 Psychiatry and Mental Health
0302 clinical medicine
Perception and Action [DCN 1]
Genetics(clinical)
Child
Genetics (clinical)
Oligonucleotide Array Sequence Analysis
0303 health sciences
Antisocial Personality Disorder
10058 Department of Child and Adolescent Psychiatry
3. Good health
Pedigree
Europe
Psychiatry and Mental health
Conduct disorder
Attention Deficit and Disruptive Behavior Disorders
ADHD -- conduct disorder -- genome wide association study -- genetic association information network
medicine.symptom
Psychology
Functional Neurogenomics [DCN 2]
Anxiety disorder
Algorithms
Clinical psychology
Conduct Disorder
Genetic Markers
2716 Genetics (clinical)
Quantitative Trait Loci
Context (language use)
610 Medicine & health
Child Behavior Disorders
Impulsivity
Polymorphism
Single Nucleotide
Mental health [NCEBP 9]
behavioral disciplines and activities
Genomic disorders and inherited multi-system disorders [IGMD 3]
03 medical and health sciences
Cellular and Molecular Neuroscience
Cognitive neurosciences [UMCN 3.2]
mental disorders
medicine
Pervasive developmental disorder
Humans
ddc:610
Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie
Psychosomatik und Psychotherapie des Kindes- und Jugendalters
030304 developmental biology
Psychiatric Status Rating Scales
Genome
Human
Antisocial personality disorder
medicine.disease
Genetic defects of metabolism [UMCN 5.1]
Attention Deficit Disorder with Hyperactivity
030217 neurology & neurosurgery
Genome-Wide Association Study
Zdroj: American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, 147B, 8, pp. 1369-78
American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, 147B, 1369-78
ISSN: 1552-4841
DOI: 10.1002/ajmg.b.30871
Popis: Contains fulltext : 71374.pdf (Publisher’s version ) (Closed access) Attention-deficit/hyperactivity disorder (ADHD) is typically characterized by inattention, excessive motor activity, impulsivity, and distractibility. Individuals with ADHD have significant impairment in family and peer relations, academic functioning, and show high co-morbidity with a wide range of psychiatric disorders including oppositional defiant disorder (ODD), conduct disorder (CD), anxiety disorder, depression, substance abuse, and pervasive developmental disorder (PDD). Family studies suggest that ADHD + CD represents a specific subtype of the ADHD disorder with familial risk factors only partly overlapping with those of ADHD alone. We performed a hypothesis-free analysis of the GAIN-ADHD sample to identify markers and genes important in the development of conduct problems in a European cohort of individuals with ADHD. Using the Family-Based Association Test (FBAT) package we examined three measures of conduct problems in 1,043,963 autosomal markers. This study is part of a series of exploratory analyses to identify candidate genes that may be important in ADHD and ADHD-related traits, such as conduct problems. We did not find genome-wide statistical significance (P < 5 x 10(-7)) for any of the tested markers and the three conduct problem traits. Fifty-four markers reached strong GWA signals (P < 10(-5)). We discuss these findings in the context of putative candidate genes and the implications of these findings in the understanding of the etiology of ADHD + CD. We aimed to achieve insight into the genetic etiology of a trait using a hypothesis-free study design and were able to identify a number of biologically interesting markers and genes for follow-up studies.
Databáze: OpenAIRE
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