Calcium and the Ca-ATPase SPCA1 modulate plasma membrane abundance of ZIP8 and ZIP14 to regulate Mn(II) uptake in brain microvascular endothelial cells
Autor: | Brittany L. Steimle, Danielle K. Bailey, Frances M. Smith, Shaina L. Rosenblum, Daniel J. Kosman |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | The Journal of biological chemistry. 298(8) |
ISSN: | 1083-351X |
Popis: | Manganese (II) accumulation in human brain microvascular endothelial cells is mediated by the metal-ion transporters ZRT IRT-like protein 8 (ZIP8) and ZRT IRT-like protein 14 (ZIP14). The plasma membrane occupancy of ZIP14, in particular, is increased in cells treated with Mn |
Databáze: | OpenAIRE |
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