Calcium and the Ca-ATPase SPCA1 modulate plasma membrane abundance of ZIP8 and ZIP14 to regulate Mn(II) uptake in brain microvascular endothelial cells

Autor: Brittany L. Steimle, Danielle K. Bailey, Frances M. Smith, Shaina L. Rosenblum, Daniel J. Kosman
Rok vydání: 2022
Předmět:
Zdroj: The Journal of biological chemistry. 298(8)
ISSN: 1083-351X
Popis: Manganese (II) accumulation in human brain microvascular endothelial cells is mediated by the metal-ion transporters ZRT IRT-like protein 8 (ZIP8) and ZRT IRT-like protein 14 (ZIP14). The plasma membrane occupancy of ZIP14, in particular, is increased in cells treated with Mn
Databáze: OpenAIRE