Pramipexole effects on startle gating in rats and normal men
| Autor: | Sebastiaan D. T. Sassen, Ashley N. Sutherland Owens, Sophia A. Lelham, Wei-li Chang, Jo Talledo, Neal R. Swerdlow |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Agonist medicine.medical_specialty Adolescent medicine.drug_class Dopamine Sensorimotor gating Placebo Dopamine agonist Rats Sprague-Dawley Pramipexole Dopamine receptor D3 Internal medicine medicine Animals Humans Benzothiazoles Pharmacology/Toxicology Prepulse inhibition Original Investigation Psychiatry Pharmacology Cross-Over Studies Sensory gating business.industry Neurosciences Receptors Dopamine D3 Startle Sensory Gating Crossover study Rats Biomedicine medicine.anatomical_structure Endocrinology Dopamine Agonists Sleep Stages business Personality medicine.drug |
| Zdroj: | Psychopharmacology Swerdlow, Neal R.; Lelham, Sophia A.; Sutherland Owens, Ashley N.; Chang, Wei-Li; Sassen, Sebastiaan D.; & Talledo, Jo A.(2009). Pramipexole effects on startle gating in rats and normal men. Psychopharmacology, 205(4), pp 689-698. doi: 10.1007/s00213-009-1577-5. Retrieved from: http://www.escholarship.org/uc/item/9bf0p268 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/s00213-009-1577-5 |
| Popis: | Background Dopamine D3 receptors regulate sensorimotor gating in rats, as evidenced by changes in prepulse inhibition (PPI) of startle after acute administration of D3 agonists and antagonists. In this study, we tested the effects of the D3-preferential agonist, pramipexole, on PPI in normal men and Sprague–Dawley rats. Materials and Methods Acoustic startle and PPI were tested in clinically normal men, comparing the effects of placebo vs. 0.125 mg (n = 20) or placebo vs. 0.1875 mg (n = 20) pramipexole, in double blind, crossover designs. These measures were also tested in male Sprague–Dawley rats using a parallel design [vehicle vs. 0.1 mg/kg (n = 8), vehicle vs. 0.3 mg/kg (n = 8) or vehicle vs. 1.0 mg/kg pramipexole (n = 8)]. Autonomic and subjective measures of pramipexole effects and several personality instruments were also measured in humans. Results Pramipexole increased drowsiness and significantly increased PPI at 120-ms intervals in humans; the latter effect was not moderated by baseline PPI or personality scale scores. In rats, pramipexole causes a dose-dependent reduction in long-interval (120 ms) PPI, while low doses actually increased short-interval (10–20 ms) PPI. Effects of pramipexole on PPI in rats were independent of baseline PPI and changes in startle magnitude. Conclusion The preferential D3 agonist pramipexole modifies PPI in humans and rats. Unlike indirect DA agonists and mixed D2/D3 agonists, pramipexole increases long-interval PPI in humans, in a manner that is independent of baseline PPI and personality measures. These findings are consistent with preclinical evidence for differences in the D2- and D3-mediated regulation of sensorimotor gating. |
| Databáze: | OpenAIRE |
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