Management of Ependymoma in Children, Adolescents and Young Adults
| Autor: | N. Thorp, L. Gandola |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Ependymoma Pediatrics medicine.medical_specialty Adolescent medicine.medical_treatment Localised disease Systemic therapy 030218 nuclear medicine & medical imaging Central Nervous System Neoplasms Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging Young adult Child High rate business.industry medicine.disease Gross Total Resection Radiation therapy Oncology Child Preschool 030220 oncology & carcinogenesis Early adolescents Female business |
| Zdroj: | Clinical Oncology. 31:162-170 |
| ISSN: | 0936-6555 |
| DOI: | 10.1016/j.clon.2018.12.001 |
| Popis: | Paediatric ependymomas are rare, malignant tumours arising throughout the central nervous system, but most frequently (in children) the posterior fossa. The standard of care for localised disease is gross total resection and focal radiotherapy, resulting in overall survival rates of up to 85%. Despite improvements in survival, treatment remains challenging, with persistently high rates of (rarely curable) relapse alongside risks of significant tumour and treatment-related toxicity. Systemic therapy is currently used to delay radiotherapy in very young children and in the management of metastatic or recurrent disease. Its use in the adjuvant setting is the subject of ongoing studies. Current research efforts are aimed at eliciting a better understanding of molecular biology, correlating this with tumour behaviour and defining targets for potential new agents. Prognosis seems to be related to the extent of surgical resection and the age at presentation. This article reviews clinical aspects of ependymoma management in children and young people. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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