Corneal Collagen Cross-Linking for the Management of Mycotic Keratitis
| Autor: | Macit Ilkit, Elif Erdem, Ibrahim Inan Harbiyeli, Reha Ersoz, Hazal Boral, Meltem Yagmur |
|---|---|
| Přispěvatelé: | Çukurova Üniversitesi |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Antifungal Agents Corneal Infection Adolescent Turkey Ultraviolet Rays Visual analogue scale Veterinary (miscellaneous) Mycotic keratitis Corneal collagen cross-linking Applied Microbiology and Biotechnology Microbiology law.invention Hospitals University Tertiary Care Centers Young Adult 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law medicine Humans In patient Aged Retrospective Studies Keratitis Voriconazole business.industry Middle Aged University hospital Surgery Treatment Outcome Corneal infection 030221 ophthalmology & optometry Female Collagen business Eye Infections Fungal Agronomy and Crop Science Topical voriconazole 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Mycopathologia. 183:521-527 |
| ISSN: | 1573-0832 0301-486X |
| DOI: | 10.1007/s11046-018-0247-8 |
| Popis: | PubMedID: 29453698 Purpose: To evaluate the efficiency of corneal collagen cross-linking (CXL) in addition to topical voriconazole in cases with mycotic keratitis. Design: Retrospective case series in a tertiary university hospital. Participants: CXL was performed on 13 patients with mycotic keratitis who presented poor or no response to topical voriconazole treatment. Methods: The clinical features, symptoms, treatment results and complications were recorded retrospectively. The corneal infection was graded according to the depth of infection into the stroma (from grade 1 to grade 3). The visual analogue scale was used to calculate the pain score before and 2 days after surgery. Main Outcome Measures: Grade of the corneal infection. Results: Mean age of 13 patients (6 female and 7 male) was 42.4 ± 17.7 years (20–74 years). Fungus was demonstrated in culture (eight patients) or cytological examination (five patients). Seven of the 13 patients (54%) were healed with topical voriconazole and CXL adjuvant treatment in 26 ± 10 days (15–40 days). The remaining six patients did not respond to CXL treatment; they initially presented with higher grade ulcers. Pre- and post-operative pain score values were 8 ± 0.8 and 3.5 ± 1, respectively (p |
| Databáze: | OpenAIRE |
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