The Ki-67 proliferation index predicts recurrence-free survival in patients with dermatofibrosarcoma protuberans

Autor: Ramazan Kahveci, Erdem Cubukcu, Ulviye Yalcinkaya, Deligonul Adem, Sibel Kahraman Çetintaş, Ahmet Z. Sahin, Turkkan Evrensel, Ozgur Tanriverdi, Mine Özşen, Serkan Yazici, Sibel Oyucu Orhan, Birol Ocak
Přispěvatelé: MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tanrıverdi, Özgür
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Oncology
Adult
Male
Multivariate statistics
medicine.medical_specialty
Skin Neoplasms
Proliferation index
Dermatofibrosarcoma protuberans
Disease-Free Survival
03 medical and health sciences
Young Adult
Ki-67 proliferation index
disease recurrence
0302 clinical medicine
Predictive Value of Tests
Internal medicine
medicine
Humans
Aged
Cell Proliferation
Proportional Hazards Models
Retrospective Studies
lcsh:R5-920
biology
business.industry
Soft tissue sarcoma
Hazard ratio
Dermatofibrosarcoma
General Medicine
Middle Aged
Prognosis
medicine.disease
Disease recurrence
Confidence interval
030104 developmental biology
medicine.anatomical_structure
Ki-67 Antigen
030220 oncology & carcinogenesis
Ki-67
biology.protein
Female
prognosis
Neoplasm Recurrence
Local
business
lcsh:Medicine (General)
Subcutaneous tissue
Research Article
Zdroj: Bosnian Journal of Basic Medical Sciences (2020)
Bosnian Journal of Basic Medical Sciences
Popis: Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue sarcoma that originates from the dermis or subcutaneous tissue in the skin. While its prognosis is generally favorable, disease recurrence is relatively frequent. Because morbidity after repeated surgery may be significant, an optimized prediction of recurrence-free survival (RFS) has the potential to improve current management strategies. The purpose of this study was to investigate the prognostic value of the Ki-67 proliferation index with respect to RFS in patients with DFSP. We retrospectively analyzed data from 45 patients with DFSP. We calculated the Ki-67 proliferation index as the percentage of immunostained nuclei among the total number of tumor cell nuclei regardless of the intensity of immunostaining. We constructed univariate and multivariate Cox proportional hazards regression models to identify predictors of RFS. Among the 45 patients included in the study, 8 developed local recurrences and 2 had lung metastases (median follow-up: 95.0 months; range: 5.2−412.4 months). The RFS rates at 60, 120, and 240 months of follow-up were 83.8%, 76.2%, and 65.3%, respectively. The median Ki-67 proliferation index was 14%. Notably, we identified the Ki-67 proliferation index as the only independent predictor for RFS in multivariate Cox proportional hazards regression analysis (hazard ratio = 1.106, 95% confidence interval = 1.019−1.200, p = 0.016). In summary, our results highlight the potential usefulness of the Ki-67 proliferation index for facilitating the identification of patients with DFSP at higher risk of developing disease recurrences.
Databáze: OpenAIRE
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