Protective effect of atorvastatin on oxidative stress in streptozotocin-induced diabetic rats independently their lipid-lowering effects

Autor: Songül Ünüvar, Umut Uyumlu, Göknur Aktay, Şule Gürsoy, Nevin Ilhan
Rok vydání: 2018
Předmět:
0301 basic medicine
Blood Glucose
medicine.medical_specialty
Thiobarbituric acid
Health
Toxicology and Mutagenesis
Atorvastatin
Toxicology
medicine.disease_cause
Nitric Oxide
Biochemistry
Thiobarbituric Acid Reactive Substances
Diabetes Mellitus
Experimental
Lipid peroxidation
Rats
Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Diabetes mellitus
Internal medicine
medicine
TBARS
Animals
Aspartate Aminotransferases
Molecular Biology
030102 biochemistry & molecular biology
medicine.diagnostic_test
nutritional and metabolic diseases
Alanine Transaminase
General Medicine
medicine.disease
Streptozotocin
Lipids
Rats
Oxidative Stress
Endocrinology
chemistry
Organ Specificity
030220 oncology & carcinogenesis
Molecular Medicine
lipids (amino acids
peptides
and proteins)
Female
Lipid Peroxidation
Lipid profile
Oxidative stress
medicine.drug
Zdroj: Journal of biochemical and molecular toxicology. 33(5)
ISSN: 1099-0461
Popis: In the present study, we investigate the effects of atorvastatin on the lipid profile, oxidative stress, and liver enzyme markers, and its protective activity against diabetic complications, in streptozotocin (STZ)-induced diabetic rats. Fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), and high-density lipoprotein (HDL) levels, as well as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzyme activities, were measured 7 weeks after the administration of STZ and atorvastatin. Thiobarbituric acid reactive substances (TBARS), non-protein associated sulfhydryl (NP-SH), total sulfhydryl (T-SH), and nitric oxide (NO) levels were measured to evaluate oxidative stress. Atorvastatin was found to inhibit ALT and AST activities and to reduce FBG levels in rats with STZ-induced diabetes. Moreover, atorvastatin treatment significantly reduced lipid peroxidation in kidney, heart, and eye tissues (P < 0.001, for all), and resulted in a significant increase in NP-SH levels in brain tissues (P < 0.001). Total NO and nitrate levels increased significantly after atorvastatin treatment (P < 0.01). Our results revealed that atorvastatin has a protective effect against STZ-induced oxidative damage by reducing TBARS levels and increasing NP-SH levels, has a hepatoprotective effect by decreasing ALT and AST activities. It also shows the antihyperglycemic activity by lowering FBG levels.
Databáze: OpenAIRE
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