Periodontitis decreases the antiatherogenic potency of high density lipoprotein
| Autor: | Kimmo Mattila, Jouko Sundvall, Georg Alfthan, Marja Vesanen, Pirkko J. Pussinen, Matti Jauhiainen, Tiina Vilkuna-Rautiainen, Sirkka Asikainen, Timo Palosuo |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Phospholipid QD415-436 030204 cardiovascular system & hematology Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology High-density lipoprotein Phospholipid transfer protein Internal medicine Cholesterylester transfer protein medicine Potency Humans Particle Size Periodontitis Phospholipids biology Cholesterol HDL metabolism Reverse cholesterol transport 030206 dentistry Cell Biology Middle Aged medicine.disease 3. Good health reverse cholesterol transport Kinetics C-Reactive Protein chemistry inflammation biology.protein Diet Atherogenic lipids (amino acids peptides and proteins) Female atherosclerosis Lipoproteins HDL cholesterol efflux |
| Zdroj: | Journal of Lipid Research, Vol 45, Iss 1, Pp 139-147 (2004) |
| ISSN: | 0022-2275 |
| Popis: | Periodontitis, a consequence of persistent bacterial infection and chronic inflammation, has been suggested to predict coronary heart disease (CHD). The aim of this study was to investigate the impact of periodontitis on HDL structure and antiatherogenic function in cholesterol efflux in vitro. HDL was isolated from 30 patients (age 43.6 ± 6.1 years, mean ± SD) with periodontitis before and after (3.2 ± 1.4 months) periodontal treatment. The capacity of HDL for cholesterol efflux from macrophages (RAW 264.7), HDL composition, and key proteins of HDL metabolism were determined. After periodontal treatment, phospholipid transfer protein (PLTP) activity was 6.2% (P < 0.05) lower, and serum HDL cholesterol concentration, PLTP mass, and cholesteryl ester transfer protein activity were 10.7% (P < 0.001), 7.1% (P = 0.078), and 19.4% (P < 0.001) higher, respectively. The mean HDL2/HDL3 ratio increased from 2.16 ± 0.87 to 3.56 ± 0.48 (P < 0.05). HDL total phospholipid mass and sphingomyelin-phosphatidylcholine ratio were 7.4% (P < 0.05) and 36.8% (P < 0.001) higher, respectively. The HDL-mediated cholesterol efflux tended to be higher after periodontal treatment; interestingly, this increase was significant (P < 0.05) among patients whose C-reactive protein decreased (53.7% reduction, P = 0.015) and who were positive by PCR for Actinobacillus actinomycetemcomitans.These results suggest that periodontitis causes similar, but milder, changes in HDL metabolism than those that occur during the acute-phase response and that periodontitis may diminish the antiatherogenic potency of HDL, thus increasing the risk for CHD. |
| Databáze: | OpenAIRE |
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