An Update on the Pathogenic Role of Neutrophils in Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still's Disease
| Autor: | Hyoun-Ah Kim, Mi-Hyun Ahn, Ji-Won Kim, Ju-Yang Jung, Chang-Hee Suh |
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| Rok vydání: | 2021 |
| Předmět: |
systemic juvenile idiopathic arthritis
QH301-705.5 Neutrophils Phagocytosis neutrophil extracellular traps Arthritis Disease Review medicine.disease_cause Extracellular Traps Catalysis Autoimmunity Inorganic Chemistry Pathogenesis medicine Alarmins Humans adult-onset Still’s disease Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Spectroscopy Innate immune system business.industry Organic Chemistry Pathogen-Associated Molecular Pattern Molecules neutrophil General Medicine Neutrophil extracellular traps medicine.disease Arthritis Juvenile Immunity Innate Computer Science Applications Chemistry Rheumatoid arthritis Immunology Cytokines innate immune business Still's Disease Adult-Onset Biomarkers |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 13038, p 13038 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Neutrophils are innate immune phagocytes that play a key role in immune defense against invading pathogens. The main offensive mechanisms of neutrophils are the phagocytosis of pathogens, release of granules, and production of cytokines. The formation of neutrophil extracellular traps (NETs) has been described as a novel defense mechanism in the literature. NETs are a network of fibers assembled from chromatin deoxyribonucleic acid, histones, and neutrophil granule proteins that have the ability to kill pathogens, while they can also cause toxic effects in hosts. Activated neutrophils with NET formation stimulate autoimmune responses related to a wide range of inflammatory autoimmune diseases by exposing autoantigens in susceptible individuals. The association between increased NET formation and autoimmunity was first reported in antineutrophil cytoplasmic antibody-related vasculitis, and the role of NETs in various diseases, including systemic lupus erythematosus, rheumatoid arthritis, and psoriasis, has since been elucidated in research. Herein, we discuss the mechanistic role of neutrophils, including NETs, in the pathogenesis of systemic juvenile idiopathic arthritis (SJIA) and adult-onset Still’s disease (AOSD), and provide their clinical values as biomarkers for monitoring and prognosis. |
| Databáze: | OpenAIRE |
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