Deuterium dilution technique for body composition assessment: resolving methodological issues in children with moderate acute malnutrition
| Autor: | Henrik Friis, Anura V Kurpad, Jonathan C. K. Wells, Charles W Yaméogo, Christian Fabiansen, Sarita Devi |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Radioisotope Dilution Technique medicine.medical_specialty Dilution technique Body water Pilot Projects Context (language use) Severity of Illness Index Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine Body Water Spectroscopy Fourier Transform Infrared Severity of illness medicine Humans Environmental Chemistry 030212 general & internal medicine Intervention trial Deuterium Oxide Saliva Intensive care medicine General Environmental Science 030109 nutrition & dietetics business.industry Malnutrition Infant medicine.disease Adipose Tissue Acute Disease Body Composition Observational study business Field conditions |
| Zdroj: | Isotopes in Environmental and Health Studies. 53:344-355 |
| ISSN: | 1477-2639 1025-6016 |
| Popis: | Childhood malnutrition is highly prevalent and associated with high mortality risk. In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body composition in studies of infants and young children in several settings, but its feasibility and accuracy in children suffering from moderate acute malnutrition requires further study. Prior to a large nutritional intervention trial among children with moderate acute malnutrition, we conducted pilot work to develop and adapt the deuterium dilution technique. We refined procedures for administration of isotope doses and collection of saliva. Furthermore, we established that equilibration time in local context is 3 h. These findings and the resulting standard operating procedures are important to improve data quality when using the deuterium dilution technique in malnutrition studies in field conditions, and may encourage a wider use of isotope techniques. |
| Databáze: | OpenAIRE |
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