Iron Overload in Transfusion-Dependent Indonesian Thalassemic Patients

Autor: Anita Rahmawati, Dimmy Prasetya, Andre Indrajaya, Teddy Arnold Sihite, Dilli Marayuzan Akbar Pratama, Ramdan Panigoro, Mas Rizky A. A. Syamsunarno, Sri Hudaya Widihastha, Mohammad Ghozali, Djatnika Setiabudi, Shofura Afifah, Suthat Fucharoen, Pandji Irani Fianza
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Anemia
Anemia, Vol 2021 (2021)
ISSN: 2090-1267
DOI: 10.1155/2021/5581831
Popis: Thalassemia is a genetic disease caused by disruption of globin chain synthesis leading to severe anemia and thus regular blood transfusion is necessary. However, there have been known transfusions-related consequences, including iron overload and multi-organ damage. The aims of this study were to evaluate liver and cardiac function in youth and adult transfusion-dependent Indonesian thalassemic patients and to assess its correlation with serum ferritin levels, as well as T2 ∗ magnetic resonance imaging (MRI). Transfusion-dependent thalassemic (TDT) outpatients (n = 66; mean age, 21.5 ± 7.2 years) were carried out for the complete assessment consisting of blood test including liver enzyme and serum ferritin, followed by electrocardiography (ECG) and echocardiography. Subjects were also divided by serum ferritin levels into three groups: < 2500 ng/mL, 2500–5000 ng/mL, and >5000 ng/mL. Additionally, subgroup analysis in patients with T2∗ MRI assessment was conducted. In terms of age of first blood transfusion, subjects with ferritin >5000 ng/mL were the youngest among others. The alanine aminotransferase (ALT) levels in group with serum ferritin >5000 ng/mL were significantly higher than those of the group with serum ferritin 5000 ng/mL had significantly lower tricuspid annular plane systolic excursion (TAPSE) when compared with those who had serum ferritin
Databáze: OpenAIRE
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