A model for the passage of the nurohypophysial hormones and their related proteins through the rat neurohypophysis
| Autor: | C. W. Jones, Peter Clifford, G. D. Burford, B. T. Pickering |
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| Rok vydání: | 1973 |
| Předmět: |
History
medicine.medical_specialty Vasopressin Vasopressins Hypothalamus Exponential regression Sulfur Radioisotopes Models Biological Education Reaction rate constant Pituitary Gland Posterior Internal medicine medicine Animals Cysteine Neurophysins Chemistry Computers Cellular Interactions and Control Processes Proteins Computer Science Applications Rats Endocrinology Biophysics Mathematics Hormone |
| Zdroj: | The Biochemical journal. 136(4) |
| ISSN: | 0264-6021 |
| Popis: | The change in the radioactivity of vasopressin–neurophysin in the rat neurohypophysis after an intracisternal injection of [35S]cysteine was fitted to several mathematical models. The data fitted best a model in which there is a linear input of radioactive protein into one pool of the neurohypophysis, from which it is either released by an exponential process or transferred to a second pool from which it is released by a second exponential process with a rate constant much lower than the first. This model is compatible with the existence of a ‘readily releasable’ pool first postulated by Sachs et al. (1967). Data for the change in radioactivity of vasopressin also gave a good fit in this model. Calculation of the rate constants suggested that the first pool represented about 2% of the total hormone. |
| Databáze: | OpenAIRE |
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