Tuning Properties of Iron Oxide Nanoparticles in Aqueous Synthesis without Ligands to Improve MRI Relaxivity and SAR
| Autor: | Beatriz Sanz, A. Martinez, Matthias Stuber, Debora Bonvin, Gerardo F. Goya, Heinrich Hofmann, Duncan T. L. Alexander, Marijana Mionić Ebersold, Jessica A. M. Bastiaansen, Rafael Piñol, Ángel Millán, Kurt Schenk |
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| Přispěvatelé: | Swiss National Science Foundation, European Commission, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España) |
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Saturation magnetization MRI relaxivity General Chemical Engineering Inorganic chemistry Magnetic nanoparticle Physics::Medical Physics magnetic nanoparticle Physics::Optics 02 engineering and technology Hydrothermal treatment 010402 general chemistry 01 natural sciences Article aqueous synthesis lcsh:Chemistry Monocrystalline silicon Colloid chemistry.chemical_compound Crystallinity Iron oxide nanoparticles hydrothermal treatment General Materials Science iron oxide nanoparticles saturation magnetization specific absorption rate Aqueous solution Aqueous synthesis 021001 nanoscience & nanotechnology equipment and supplies Surface energy 0104 chemical sciences lcsh:QD1-999 chemistry Crystallite 0210 nano-technology |
| Zdroj: | Nanomaterials Nanomaterials, vol. 7, no. 8, pp. 10.3390 Nanomaterials; Volume 7; Issue 8; Pages: 225 Digital.CSIC. Repositorio Institucional del CSIC instname Zaguán. Repositorio Digital de la Universidad de Zaragoza Nanomaterials, Vol 7, Iss 8, p 225 (2017) |
| ISSN: | 2079-4991 2014-5497 |
| Popis: | This article belongs to the Special Issue Magnetic Nanoparticles in Biological Applications. Aqueous synthesis without ligands of iron oxide nanoparticles (IONPs) with exceptional properties still remains an open issue, because of the challenge to control simultaneously numerous properties of the IONPs in these rigorous settings. To solve this, it is necessary to correlate the synthesis process with their properties, but this correlation is until now not well understood. Here, we study and correlate the structure, crystallinity, morphology, as well as magnetic, relaxometric and heating properties of IONPs obtained for different durations of the hydrothermal treatment that correspond to the different growth stages of IONPs upon initial co-precipitation in aqueous environment without ligands. We find that their properties were different for IONPs with comparable diameters. Specifically, by controlling the growth of IONPs from primary to secondary particles firstly by colloidal and then also by magnetic interactions, we control their crystallinity from monocrystalline to polycrystalline IONPs, respectively. Surface energy minimization in the aqueous environment along with low temperature treatment is used to favor nearly defect-free IONPs featuring superior properties, such as high saturation magnetization, magnetic volume, surface crystallinity, the transversal magnetic resonance imaging (MRI) relaxivity (up to r₂ = 1189 mM-1·s-1 and r₂/r₁ = 195) and specific absorption rate, SAR (up to 1225.1 W·gFe-1). This work was financially supported by the MagnetoTeranostics project that was scientifically evaluated by the Swiss National Science Foundation (SNSF), financed by the Swiss Confederation and funded by Nano-Tera.ch (Magnetotheranostics project Nº 530 627) and by the Nanoneck2 project funded by Eurostars (Project E!9309 Nanoneck2). Financial support from the Spanish Ministry of Science and Innovation research grant MAT2014-54975-R are gratefully acknowledged. |
| Databáze: | OpenAIRE |
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