Mauve factor re-identified as 2,4-dimethyl-3-ethylpyrrole and its sedative effect on the CNS
| Autor: | Raymond A. Beck, Arthur Sohler, Joseph J. Noval |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Hallucinogen
Central Nervous System Sedative effect Chlorpromazine Chromatography Paper Metabolite medicine.medical_treatment Central nervous system Isolation procedures Pharmacology chemistry.chemical_compound medicine Animals Humans Hypnotics and Sedatives Pyrroles Multidisciplinary business.industry Stimulation Chemical Trifluoperazine Pharmacological action Stimulant medicine.anatomical_structure chemistry Psychotic Disorders Spectrophotometry Charcoal Mauve factor Chloroform Chromatography Thin Layer Rabbits business |
| Zdroj: | Nature. 228(5278) |
| ISSN: | 0028-0836 |
| Popis: | Irvine1 and Hoffer and Mahon2 reported on the occurrence of a compound giving a characteristic mauve colour with Ehrlich's reagent on paper. The significance of this metabolite is that it occurs with greater frequency in psychotic individuals. This finding has been confirmed by several investigators3–5. Ellman et al.6, however, reported that a metabolite apparently identical to the one in question may be derived from phenothiazines and occurs in the urine of patients on phenothiazine therapy. Recently, Irvine7 has identified the mauve factor as 2,4-dimethyl-3-ethylpyrrole on the basis of chromatographic and mass spectral studies. This report is concerned with the identity of the mauve factor, a critique of various isolation procedures used by different investigators and its pharmacological action on the central nervous system (CNS). The possible CNS effect is important because several laboratories have postulated a metabolic product in the schizophrenic which may be stimulant and hallucinogenic. |
| Databáze: | OpenAIRE |
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