Cardiac protective effects of Moringa oleifera seeds in spontaneous hypertensive rats
| Autor: | Angela Tesse, Serge Michalet, Séverine Derbré, Gervaise Loirand, Nathalie Vaillant, Pierre Pacaud, Benjamin Lauzier, Joseph Iharinjaka Randriamboavonjy |
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| Přispěvatelé: | unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Substances d'Origine Naturelle et Analogues Structuraux (SONAS), Université d'Angers (UA), Laboratoire d'Ecologie Microbienne - UMR 5557 (LEM), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Ecole Nationale Vétérinaire de Lyon (ENVL), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Lyon (ENVL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Cardiac output Heart Diseases [SDV]Life Sciences [q-bio] Diastole Hemodynamics Blood Pressure 030204 cardiovascular system & hematology Left ventricular hypertrophy Rats Inbred WKY 03 medical and health sciences 0302 clinical medicine Heart Rate Internal medicine Rats Inbred SHR hypertension Internal Medicine medicine Animals PPAR alpha Myocardial infarction PPAR delta Moringa oleifera business.industry Myocardium cardiac hypertrophy medicine.disease Lipid Metabolism Fibrosis 3. Good health Surgery 030104 developmental biology Blood pressure medicine.anatomical_structure Ventricle Echocardiography Heart failure Hypertension Seeds Cardiology cardiovascular system Plant Preparations business Phytotherapy |
| Zdroj: | American Journal of Hypertension American Journal of Hypertension, Oxford University Press (OUP), 2016, 29 (7), pp.873-881. ⟨10.1093/ajh/hpw001⟩ American Journal of Hypertension, Oxford University Press (OUP), 2016, pp.873-881. ⟨10.1093/ajh/hpw001⟩ |
| ISSN: | 0895-7061 |
| Popis: | International audience; BACKGROUND Hypertension is characterized by a maintained high blood pressure leading to cardiac complications such as left ventricular hypertrophy and fibrosis and an increased risk of heart failure and myocardial infarction. This study investigated the cardiac effects of oral administration of Moringa oleifera (MOI) seed powder in spontaneous hypertensive rats (SHR).METHODS SHR received food containing MOI seed powder (750mg/d, 8 weeks) or normal food. In vivo measurement of hemodynamic parameters by telemetry and cardiac structure and function analysis by echocardiography were performed. Histological studies were performed to determine fibrosis and protein expression.RESULTS MOI treatment did not modify blood pressure in SHR but reduced nocturnal heart rate and improved cardiac diastolic function (reduction of isovolumetric relaxation time and deceleration time of the E wave, increase of ejection volume and cardiac output compared to nontreated SHR). Left ventricular anterior wall thickness, interseptal thickness on diastole, and relative wall thickness were reduced after MOI treatment. Furthermore, we found a significant reduction of fibrosis in the left ventricle of MOI-treated SHR. This antihypertrophic and antifibrotic effect of MOI was associated with increased expression of peroxisome proliferator-activated receptor (PPAR)-α and δ, reduced cardiac triglyceride level, and enhanced plasmatic prostacyclins.CONCLUSIONS Our data show a beneficial effect of MOI on the cardiac structure and function in SHR associated with an upregulation of PPAR-α and δ signaling. This study thus provides scientific rational support for the empirical use of MOI in the traditional Malagasy medicine against cardiac diseases associated with blood pressure overload. |
| Databáze: | OpenAIRE |
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