Heat shock protein 72/73 in normal and diseased kidneys
| Autor: | E Marquet, V S Venkataseshan |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pathology
medicine.medical_specialty Interstitial nephritis Kidney Heat shock protein Medicine Humans Vimentin HSP70 Heat-Shock Proteins Cytoskeleton biology business.industry Kidney metabolism Antibodies Monoclonal Glomerulonephritis medicine.disease Immunohistochemistry Microscopy Electron medicine.anatomical_structure Kidney Tubules Shock (circulatory) Immunology biology.protein Kidney Diseases Antibody medicine.symptom business |
| Zdroj: | Nephron. 73(3) |
| ISSN: | 1660-8151 |
| Popis: | The induction of heat shock (stress) proteins (HSP) is a response by cells due to a variety of physical, chemical, and infectious agents. They have a significant role as cytoprotectants, in the regulation of cellular functions, and in the recovery after sublethal injury. Using antibody to mammalian HSP 72/73, we have performed an immunohistological study of human renal tissue in normal and diseased states, including idiopathic nephrotic syndrome, proliferative and crescentic glomerulonephritis, and interstitial nephritis. A significant increase of HSP expression was noted in certain segments of the tubule in acute interstitial nephritis and in glomerulonephritis accompanied by active interstitial inflammation. A possible role by the inflammatory mediators in the induction of HSP in those cases is suggested. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|