Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns
| Autor: | Patricia Cabala Peralta, Norina N. Gassmann, Rogier C. J. de Jonge, Claudia R. Morales, Hugo A. van Elteren, Daniel Martin, Agustin Passano del Carpio, Maria Rivera-Ch, Tom G. Goos, Luis Huicho, Max Gassmann, Irwin K M Reiss, Saul Aranibar Machaca |
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| Přispěvatelé: | University of Zurich, Pediatric surgery, Pediatrics |
| Rok vydání: | 2016 |
| Předmět: |
Male
Physiology Acclimatization 030204 cardiovascular system & hematology 0302 clinical medicine 2737 Physiology (medical) Pregnancy Peru Prospective Studies purl.org/pe-repo/ocde/ford#3.01.08 [https] Altitude Articles Effects of high altitude on humans 10081 Institute of Veterinary Physiology In utero 10076 Center for Integrative Human Physiology Cardiology Female medicine.symptom Acclimatization/physiology Adult medicine.medical_specialty incident dark field imaging near infrared spectroscopy microcirculation Microcirculation Pregnancy/physiology 03 medical and health sciences Young Adult Vessel density 030225 pediatrics Physiology (medical) Internal medicine medicine Humans Microvessels/anatomy & histology/physiology Infant Newborn/physiology Fetus business.industry hypoxia Microcirculation/physiology Infant Newborn 1314 Physiology Hypoxia (medical) medicine.disease neonates Surgery Microvessels oxygen profiling 570 Life sciences biology business |
| Zdroj: | Gassmann, N N, van Elteren, H A, Goos, T G, Morales, C R, Rivera-Ch, M, Martin, D S, Cabala Peralta, P, Passano Del Carpio, A, Aranibar Machaca, S, Huicho, L, Reiss, I K M, Gassmann, M & de Jonge, R C J 2016, ' Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns ', Journal of applied physiology (Bethesda, Md. : 1985), vol. 121, no. 3, pp. 709-15 . https://doi.org/10.1152/japplphysiol.00561.2016 Journal of applied physiology (Bethesda, Md. : 1985), 121(3), 709-15. American Physiological Society Journal of Applied Physiology, 121(3), 709-715. American Physiological Society |
| ISSN: | 8750-7587 0161-7567 |
| DOI: | 10.1152/japplphysiol.00561.2016 |
| Popis: | The developing human fetus is able to cope with the physiological reduction in oxygen supply occurring in utero. However, it is not known if microvascularization of the fetus is augmented when pregnancy occurs at high altitude. Fifty-three healthy term newborns in Puno, Peru (3,840 m) were compared with sea-level controls. Pre- and postductal arterial oxygen saturation (SpO2) was determined. Cerebral and calf muscle regional tissue oxygenation was measured using near infrared spectroscopy (NIRS). Skin microcirculation was noninvasively measured using incident dark field imaging. Pre- and postductal SpO2 in Peruvian babies was 88.1 and 88.4%, respectively, which was 10.4 and 9.7% lower than in newborns at sea level ( P < 0.001). Cerebral and regional oxygen saturation was significantly lower in the Peruvian newborns (cerebral: 71.0 vs. 74.9%; regional: 68.5 vs. 76.0%, P < 0.001). Transcutaneously measured total vessel density in the Peruvian newborns was 14% higher than that in the newborns born at sea level (29.7 vs. 26.0 mm/mm2; P ≤ 0.001). This study demonstrates that microvascular vessel density in neonates born to mothers living at high altitude is higher than that in neonates born at sea level. |
| Databáze: | OpenAIRE |
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