Correlation of Serum Vitamin A Levels with Disease Activity Indices and Colonic IL-23R and FOXP3 mRNA Expression in Ulcerative Colitis Patients
| Autor: | Prashant Verma, Veena Tiwari, Swati Subodh, Vineet Ahuja, Amit Tuteja, Ritika Rampal, Siddhartha Datta Gupta, GS Toteja |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Vitamin medicine.medical_specialty Colon Immunology Severity of Illness Index T-Lymphocytes Regulatory Inflammatory bowel disease Gastroenterology Cohort Studies Pathogenesis Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans RNA Messenger Colitis Vitamin A Receptor Regulation of gene expression business.industry FOXP3 Forkhead Transcription Factors Receptors Interleukin General Medicine Middle Aged medicine.disease Ulcerative colitis 030104 developmental biology Gene Expression Regulation chemistry Disease Progression Th17 Cells Colitis Ulcerative Female 030211 gastroenterology & hepatology business |
| Zdroj: | Scandinavian Journal of Immunology. 84:110-117 |
| ISSN: | 0300-9475 |
| DOI: | 10.1111/sji.12450 |
| Popis: | Genome-wide association studies have identified IL-23 receptor (IL-23R) as a susceptibility locus for the pathogenesis of ulcerative colitis (UC), which is characterized by exaggerated Th2/Th17 response. Studies have shown that vitamin A (VA) reduces disease progression by promoting FOXP3⁺ T cells and curbing Th17 cells. In this study, we explored the association of colonic IL-23R and FOXP3 expression in fifty-one UC patients (23 in remission and 28 with active disease) with serum VA levels and disease activity. We observed that decreased serum VA levels were associated with increased disease activity. However, there was no significant difference in mucosal IL-23R and FOXP3 expression in UC patients with moderate-to-severe disease activity compared to those in remission. Also, no significant correlation was drawn between serum VA levels and mucosal IL-23R and FOXP3 expression. Our study suggests that even after an established role of VA in inhibiting Th17 responses in mice models and humans, serum VA levels and disease activity do not correlate with FOXP3 and IL-23R expression in colonic mucosa of UC patients. |
| Databáze: | OpenAIRE |
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