Antinociceptive and anti-inflammatory activities of ethanolic extract of Alafia barteri
| Autor: | Chidebelu Ezeani, Essien Imeh, Abidemi J. Akindele, Flora R. Aigbe, Margaret O. Sofidiya |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
biology
Apocynaceae medicine.drug_class Antinociceptive activity Polyphenol content Anti-inflammatory effect lcsh:RS1-441 Pharmacology biology.organism_classification Anti-inflammatory Carrageenan Alafia barteri lcsh:Pharmacy and materia medica Pharmacology Toxicology and Pharmaceutics(all) chemistry.chemical_compound Nociception chemistry medicine General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 24, Iss 3, Pp 348-354 (2014) Revista Brasileira de Farmacognosia, Volume: 24, Issue: 3, Pages: 348-354, Published: JUN 2014 Revista Brasileira de Farmacognosia v.24 n.3 2014 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Revista Brasileira de Farmacognosia, Vol 24, Iss 3, Pp 348-354 |
| Popis: | This study analyzes the antinociceptive and anti-inflammatory properties of ethanolic leaf extract of Alafia barteri Oliv., Apocynaceae, based on its medicinal use in the treatment of toothaches, inflammation and fevers. The antinociceptive effect was assessed in mice using acetic acid-induced writhing, tail clip, tail immersion and formalin assays. Anti-inflammatory activity was evaluated on carrageenan-induced paw oedema in rats, and xylene-induced ear oedema in mice. In acetic acid-induced writhing test, the extract at different doses (50, 100 and 200 mg/kg, p.o.) significantly (p < 0.05) and dose-dependently reduced pain by 35.04, 56.49 and 84.25%, respectively. The extract also significantly inhibited both the early and late phases of formalin-induced nociception in mice. In the tail immersion test, the extract caused a significant inhibition of pain (34.43% inhibition, after 90 min) at a dose of 200 mg/kg, while the effect of the extract in the tail clip test was only significant at the 100 mg/kg dose. A. barteri caused a significant inhibition of paw oedema development in the carrageenan and xylene-induced oedema tests. There was no mortality recorded following treatment with the extract (5 g/kg, p.o.). The results support the traditional use of A. barteri in the treatment of various diseases associated with pain and inflammation. Keywords: Alafia barteri, Apocynaceae, Anti-inflammatory effect, Antinociceptive activity, Polyphenol content |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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