Comparison of trimethoprim–sulfamethoxazole and aerosolized pentamidine for primary prophylaxis of Pneumocystis jiroveci pneumonia in immunocompromised patients with connective tissue disease
| Autor: | Miho Kimura, Hirobumi Kondo, Akira Ishikawa, Sumiaki Tanaka, Shunsei Hirohata, Hirahito Endo |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pneumocystis jiroveci pneumonia medicine.medical_specialty medicine.medical_treatment Lymphocyte Immunology Immunocompromised Host Rheumatology Internal medicine Trimethoprim Sulfamethoxazole Drug Combination Humans Immunology and Allergy Medicine Connective Tissue Diseases Pentamidine Aged Retrospective Studies Aerosols business.industry Pneumonia Pneumocystis Sulfamethoxazole Immunosuppression Middle Aged medicine.disease Trimethoprim Connective tissue disease CD4 Lymphocyte Count medicine.anatomical_structure Female CTD business medicine.drug |
| Zdroj: | Rheumatology International. 28:673-676 |
| ISSN: | 1437-160X 0172-8172 |
| DOI: | 10.1007/s00296-007-0505-4 |
| Popis: | To evaluate the efficacy of primary prophylaxis for Pneumocystis jiroveci pneumonia (PCP) in patients with connective tissue disease (CTD) and immunosuppression, we compared trimethoprim-sulfamethoxazole (TMP-SMZ) with aerosolized pentamidine. Forty-eight CTD patients of Kitasato University Hospital whose CD4+ lymphocyte count in the peripheral blood was less than 300 microl(-1) were reviewed from 2002 to 2004. Twenty-seven patients received TMP-SMZ and none of them developed PCP. Among 18 patients receiving aerosolized pentamidine, three patients developed PCP. These data indicate that TMP-SMZ is better for prophylaxis than aerosolized pentamidine. |
| Databáze: | OpenAIRE |
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