Association of macular and choroidal perfusion with long-term visual outcomes after macula-off rhegmatogenous retinal detachment
| Autor: | Laurence S. Lim, Alfred Tau Liang Gan, Gavin Sw Tan, Bingyao Tan, Jacqueline Chua, Ning Cheung, Edmund Wong, Mengyuan Ke, Leopold Schmetterer, Shu Yen Lee |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Visual acuity Capillary plexus Visual Acuity Cellular and Molecular Neuroscience Ophthalmology medicine Humans Macula Lutea Prospective Studies Fluorescein Angiography Prospective cohort study Retrospective Studies Retina Choroid business.industry Retinal Detachment Retinal Vessels Retinal detachment Foveal avascular zone medicine.disease eye diseases Sensory Systems Perfusion medicine.anatomical_structure medicine.symptom business Tomography Optical Coherence Random intercept |
| Zdroj: | British Journal of Ophthalmology. 106:1258-1263 |
| ISSN: | 1468-2079 0007-1161 |
| Popis: | Background/aimsTo examine the relationship between macular perfusion, as assessed using optical coherence tomography angiography (OCTA), and long-term visual outcome after surgical repair of macula-off rhegmatogenous retinal detachment (RRD).MethodsA prospective study of 29 patients who had undergone successful surgical repair of macula-off RRD. OCTA imaging was performed at month 3 and repeated at months 6 and 12 after surgery. Associations between OCTA parameters including, foveal avascular zone (FAZ) area, vessel density (VD) in the superficial capillary plexus (SCP) and deep capillary plexus (DCP), choriocapillaris flow deficit features and logMAR best-corrected visual acuity (VA) were assessed using a random intercept hybrid linear mixed model.ResultsOver the 1-year follow-up, VA improved (0.025 logMAR/ month, 95% CI 0.015 to 0.035) and FAZ area decreased (−0.020 mm2/month, 95% CI −0.032 to −0.007). Better VA after surgery was significantly associated with denser superficial VD (β=0.079, 95% CI 0.026 to 0.131), lower number of choriocapillaris flow deficits (β=−0.087, 95% CI −0.154 to −0.021) and larger average size of choriocapillaris flow deficits (β=0.085, 95% CI 0.022 to 0.147), after adjusting for baseline VA, types of surgery and other factors.ConclusionsOCTA measures of vascular perfusion in the macula may provide new pathophysiological insights and prognostic information related to macula-off RRD. |
| Databáze: | OpenAIRE |
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