Small-Molecule Inhibitors of the MLL1 CXXC Domain, an Epigenetic Reader of DNA Methylation

Autor:	Hanuman P. Kalmode, Izabella Podsiadly, Ashish Kabra, Adam Boulton, Prabhakar Reddy, Yan Gao, Christopher Li, John H. Bushweller
Rok vydání:	2023
Předmět:	Organic Chemistry Drug Discovery Biochemistry
Zdroj:	ACS medicinal chemistry letters. 13(8)
ISSN:	1948-5875
Popis:	The CXXC domain is a reader of DNA methylation which preferentially binds to unmethylated CpG DNA motifs. Chromosomal translocations involving the
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04f4edfd456ee084d3ef864f010e6ba https://pubmed.ncbi.nlm.nih.gov/35978680 Zobrazit plný text záznamu