Identification of Repressor Element 1 in Secretin/PACAP/VIP Genes

Autor:	Paula Y. Yuan, Billy K. C. Chow, Vien H. Y. Lee, Leo T. O. Lee
Rok vydání:	2006
Předmět:	Genetics General Neuroscience In silico Computational Biology Repressor Biology General Biochemistry Genetics and Molecular Biology Secretin Repressor Proteins History and Philosophy of Science Gene expression Transcriptional regulation Animals Humans Pituitary Adenylate Cyclase-Activating Polypeptide Regulatory Pathway Transcription factor Gene hormones hormone substitutes and hormone antagonists Transcription Factors Vasoactive Intestinal Peptide
Zdroj:	Annals of the New York Academy of Sciences. 1070:388-392
ISSN:	0077-8923
DOI:	10.1196/annals.1317.050
Popis:	Repressor element 1 (RE-1) is a negative, cis-acting regulatory element that interacts with the transcription factor RE-1-silencing transcription factor (REST). REST represses gene expression by two repressor domains that recruit other factors including mSin3 and CoREST. RE-1 has been identified in an increasing number of neuronal-specific genes, and recently, functional REST sites have also been discovered in VIP and PACAP genes. In the present article, we demonstrated for the first time that RE-1 sites are present in the 5' flanking regions of several secretin/PACAP/VIP genes by in silico analysis. This observation suggests that RE-1/REST is a common negative regulatory pathway of this peptide family.
Databáze:	OpenAIRE
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