Prognostic Role of Matrix Metalloproteinases 2, 7, 8, 9 and Their Type 1 Tissue Inhibitor in Blood Serum of Patients with Kidney Cancer

Autor: V. V. Mushtenko, E. S. Gershtein, D Yu Pushkar, Vsevolod Matveev, S D Bezhanova, Ivan Stilidi, N. E. Kushlinskii, A A Alferov
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Adolescent
Matrix metalloproteinase
Stage I kidney cancer
Gastroenterology
General Biochemistry
Genetics and Molecular Biology
Young Adult
03 medical and health sciences
0302 clinical medicine
Blood serum
Predictive Value of Tests
Renal cell carcinoma
Internal medicine
Biomarkers
Tumor
Overall survival
medicine
Humans
Carcinoma
Renal Cell
Aged
Aged
80 and over
Tissue Inhibitor of Metalloproteinase-1
business.industry
General Medicine
Middle Aged
Prognosis
medicine.disease
Kidney Neoplasms
Matrix Metalloproteinases
Matrix Metalloproteinase 8
030104 developmental biology
Matrix Metalloproteinase 9
Case-Control Studies
Matrix Metalloproteinase 7
Matrix Metalloproteinase 2
Female
Cell cancer
business
Kidney cancer
030217 neurology & neurosurgery
Zdroj: Bulletin of Experimental Biology and Medicine. 168:673-676
ISSN: 1573-8221
0007-4888
Popis: The study compared the levels of MMP-2,7,8,9, and TIMP-1 in blood serum of healthy people (N=97) and patients with primary renal cell carcinoma (N=93) to assess relevance of these markers to prognosis of overall survival of these patients, which were followed-up over 1 to 45 months (median 26 months). To evaluate the survival with the Kaplan-Meier estimator, the median values of examined markers in the total group of patients were taken as the threshold levels. This estimator showed that the high levels of serum MMP-7 and MMP-8 were indicative for unfavorable prognosis in the total group of patients with renal cell cancer. Of them, the most significant marker was the level of MMP-7: at its low level (
Databáze: OpenAIRE
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