Conjugate of structurally reassigned pneumococcal serotype 31 polysaccharide with CRM197 elicited potent immune response

Autor:	Tiantian Sun, Shiyan Mai, Hongzhao Mao, Huiting Li, Yunyao Duan, Shuai Meng, Jiaolin Bao, Ning Ding, Chengli Zong
Rok vydání:	2021
Předmět:	Pneumococcal Vaccines Vaccines Conjugate Polymers and Plastics Bacterial Proteins Organic Chemistry Polysaccharides Bacterial Materials Chemistry Immunity Humans Child Serogroup
Zdroj:	Carbohydrate polymers. 289
ISSN:	1879-1344
Popis:	Around 100 Streptococcus pneumonia (Spn) serotypes have been discovered, 90% of the severe diseases in children are caused by 13 serotypes. With the success of pneumococcal bacterial polysaccharide conjugate vaccines (PCVs), the burden of pneumococcal disease has been significantly reduced. Serotype 31 is a non-vaccine serotype and has increased in prevalence. By using Nuclear Magnetic Resonance (NMR) as the primary tool, we report the revised serotype 31 polysaccharide (s-31-ps) structure as [→3)-β-D-Galf-(5/6-OAc)-(1 → 3)-β-D-Galp-(1 → 3)-β-L-Rhap-(2-OAc)-(1 → 2)-α-L-Rhap-(1 → 4)-β-D-GlcpA-(1→]
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04b861553ca597f915740a3ca11d71f https://pubmed.ncbi.nlm.nih.gov/35483835 Zobrazit plný text záznamu Full Text from ScienceDirect